Rabbit Anti-CCNB2 Recombinant Antibody (8C91) (CBMAB-C9111-LY)

Name: Rabbit Anti-CCNB2 Recombinant Antibody (8C91)
SKU: CBMAB-C9111-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

8C91

Application

WB, IHC-P, IF, ELISA

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cyclin B2.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	1:50-1:200
WB	1:500-1:1,000
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA,50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cyclin B2

Introduction

CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Anauxetic Dysplasia 1 and Breast Cancer. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.

Entrez Gene ID

9133

UniProt ID

O95067

Alternative Names

Cyclin B2; G2/Mitotic-Specific Cyclin-B2; HsT17299;

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Biological Process

Cell division Source: UniProtKB-KW
G2/MI transition of meiotic cell cycle Source: Ensembl
G2/M transition of mitotic cell cycle Source: Reactome
In utero embryonic development Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Mitotic nuclear envelope disassembly Source: Reactome
Mitotic nuclear envelope reassembly Source: Reactome
Regulation of cell cycle Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of growth Source: Ensembl
Spindle assembly involved in female meiosis I Source: Ensembl
T cell homeostasis Source: Ensembl
Thymus development Source: Ensembl

Cellular Location

Centrosome; Microtubule cytoskeleton; Cytosol; Nucleus; Cyclin-dependent protein kinase holoenzyme complex; Cytoplasm; Membrane

Wu, S., Su, R., & Jia, H. (2021). Cyclin B2 (CCNB2) Stimulates the Proliferation of Triple-Negative Breast Cancer (TNBC) Cells In Vitro and In Vivo. Disease Markers, 2021.

Mamoor, S. (2021). Differential expression of cyclin B2 in human epithelial ovarian cancer.

Yang, S. Y., Ren, H., Li, C. F., & Tang, H. (2020). Screening core genes and cyclin B2 as a potential diagnosis, treatment and prognostic biomarker of hepatocellular carcinoma based on bioinformatics analysis. Zhonghua gan Zang Bing za zhi= Zhonghua Ganzangbing Zazhi= Chinese Journal of Hepatology, 28(9), 773-783.

Li, R., Jiang, X., Zhang, Y., Wang, S., Chen, X., Yu, X., ... & Huang, X. (2019). Cyclin B2 overexpression in human hepatocellular carcinoma is associated with poor prognosis. Archives of medical research, 50(1), 10-17.

Li, H., Tian, X., Wang, P., Huang, M., Xu, R., & Nie, T. (2019). MicroRNA-582–3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2. Cellular & molecular biology letters, 24(1), 1-12.

Daldello, E. M., Luong, X. G., Yang, C. R., Kuhn, J., & Conti, M. (2019). Cyclin B2 is required for progression through meiosis in mouse oocytes. Development, 146(8), dev172734.

Li, J., Tang, J. X., Cheng, J. M., Hu, B., Wang, Y. Q., Aalia, B., ... & Liu, Y. X. (2018). Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. Journal of Cell Biology, 217(11), 3901-3911.

Gao, C. L., Wang, G. W., Yang, G. Q., Yang, H., & Zhuang, L. (2018). Karyopherin subunit-α 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma. Oncology letters, 15(3), 2815-2820.

Han, S. J., Martins, J. P. S., Yang, Y., Kang, M. K., Daldello, E. M., & Conti, M. (2017). The translation of cyclin B1 and B2 is differentially regulated during mouse oocyte reentry into the meiotic cell cycle. Scientific reports, 7(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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