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Mouse Anti-CCNB2 Recombinant Antibody (X29.2) (CBMAB-C1190-CQ)

This product is a mouse antibody that recognizes CCNB2. The antibody X29.2 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IP, CyTOF.
See all CCNB2 antibodies

Summary

Host Animal
Mouse
Specificity
Frog
Clone
X29.2
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IP, CyTOF

Basic Information

Immunogen
Xenopus laevis cyclin B2
Specificity
Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin B2
Introduction
CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Anauxetic Dysplasia 1 and Breast Cancer. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.
Entrez Gene ID
UniProt ID
Alternative Names
Cyclin B2; G2/Mitotic-Specific Cyclin-B2; HsT17299;
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Biological Process
Cell division Source: UniProtKB-KW
G2/MI transition of meiotic cell cycle Source: Ensembl
G2/M transition of mitotic cell cycle Source: Reactome
In utero embryonic development Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Mitotic nuclear envelope disassembly Source: Reactome
Mitotic nuclear envelope reassembly Source: Reactome
Regulation of cell cycle Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of growth Source: Ensembl
Spindle assembly involved in female meiosis I Source: Ensembl
T cell homeostasis Source: Ensembl
Thymus development Source: Ensembl
Cellular Location
Centrosome; Microtubule cytoskeleton; Cytosol; Nucleus; Cyclin-dependent protein kinase holoenzyme complex; Cytoplasm; Membrane

Wu, S., Su, R., & Jia, H. (2021). Cyclin B2 (CCNB2) Stimulates the Proliferation of Triple-Negative Breast Cancer (TNBC) Cells In Vitro and In Vivo. Disease Markers, 2021.

Mamoor, S. (2021). Differential expression of cyclin B2 in human epithelial ovarian cancer.

Yang, S. Y., Ren, H., Li, C. F., & Tang, H. (2020). Screening core genes and cyclin B2 as a potential diagnosis, treatment and prognostic biomarker of hepatocellular carcinoma based on bioinformatics analysis. Zhonghua gan Zang Bing za zhi= Zhonghua Ganzangbing Zazhi= Chinese Journal of Hepatology, 28(9), 773-783.

Li, R., Jiang, X., Zhang, Y., Wang, S., Chen, X., Yu, X., ... & Huang, X. (2019). Cyclin B2 overexpression in human hepatocellular carcinoma is associated with poor prognosis. Archives of medical research, 50(1), 10-17.

Li, H., Tian, X., Wang, P., Huang, M., Xu, R., & Nie, T. (2019). MicroRNA-582–3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2. Cellular & molecular biology letters, 24(1), 1-12.

Daldello, E. M., Luong, X. G., Yang, C. R., Kuhn, J., & Conti, M. (2019). Cyclin B2 is required for progression through meiosis in mouse oocytes. Development, 146(8), dev172734.

Li, J., Tang, J. X., Cheng, J. M., Hu, B., Wang, Y. Q., Aalia, B., ... & Liu, Y. X. (2018). Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. Journal of Cell Biology, 217(11), 3901-3911.

Gao, C. L., Wang, G. W., Yang, G. Q., Yang, H., & Zhuang, L. (2018). Karyopherin subunit-α 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma. Oncology letters, 15(3), 2815-2820.

Han, S. J., Martins, J. P. S., Yang, Y., Kang, M. K., Daldello, E. M., & Conti, M. (2017). The translation of cyclin B1 and B2 is differentially regulated during mouse oocyte reentry into the meiotic cell cycle. Scientific reports, 7(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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