Mouse Anti-CCR9 Recombinant Antibody (CBFYC-1088) (CBMAB-C1145-FY)

Name: Mouse Anti-CCR9 Recombinant Antibody (CBFYC-1088)
SKU: CBMAB-C1145-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1088

Application

WB, IP, IF, FC

Immunogen

Murine wildtype thymocytes.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Receptor 9

Introduction

CCR9 (C-C Motif Chemokine Receptor 9) is a Protein Coding gene. Diseases associated with CCR9 include Celiac Disease 1 and Cd45 Deficiency. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

Entrez Gene ID

10803

UniProt ID

P51686

Function

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Calcium-mediated signaling Source: GO_Central
CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-85
Helical: 86-109
Extracellular: 110-120
Helical: 121-150
Cytoplasmic: 151-159
Helical: 160-185
Extracellular: 186-208
Helical: 209-243
Cytoplasmic: 244-248
Helical: 249-283
Extracellular: 284-290
Helical: 291-321
Cytoplasmic: 322-369

Amiya, T., Nakamoto, N., Irie, J., Taniki, N., Chu, P. S., Koda, Y., ... & Kanai, T. (2021). CC motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. Diabetologia, 64(3), 603-617.

Morikawa, R., Nakamoto, N., Amiya, T., Chu, P. S., Koda, Y., Teratani, T., ... & Kanai, T. (2021). Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis. Journal of Hepatology, 74(3), 511-521.

Nanamiya, R., Takei, J., Asano, T., Tanaka, T., Sano, M., Nakamura, T., ... & Kato, Y. (2021). Development of Anti-Human CC Chemokine Receptor 9 Monoclonal Antibodies for Flow Cytometry. Monoclonal antibodies in immunodiagnosis and immunotherapy, 40(3), 101-106.

Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and therapeutic medicine, 19(6), 3571-3580.

Atanes, P., Lee, V., Huang, G. C., & Persaud, S. J. (2020). The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes. Metabolism, 113, 154394.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Igaki, K., Komoike, Y., Nakamura, Y., Watanabe, T., Yamasaki, M., Fleming, P., ... & Tsuchimori, N. (2018). MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model. International immunopharmacology, 60, 160-169.

Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells. Oncology letters, 16(2), 2071-2077.

Hu, Y., Ma, A., Lin, S., Yang, Y., & Hong, G. (2017). Novel peptide screened from a phage display library antagonizes the activity of CC chemokine receptor 9. Oncology letters, 14(6), 6471-6476.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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