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Mouse Anti- CD1a Recombinant Antibody (OKT-6) (CBMAB-0918-LY)

This product is mouse antibody recognizes human CD1a. The antibody OKT-6 immunoassay techniques such as: B, F.
See all CD1a antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
OKT-6
Antibody Isotype
IgG1
Application
Blocking, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1a Molecule
Introduction
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
909
UniProt ID
P06126
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Endosome membrane; Cell membrane; Membrane raft. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Topology
Extracellular: 17-300
Helical: 301-321
Cytoplasmic: 322-327

de Jong, A., & Ogg, G. (2021). CD1a function in human skin disease. Molecular Immunology, 130, 14-19.

Gapin, L. (2021). CD1a autoreactivity: When size does matter.

Yoo, H. J., Kim, N. Y., & Kim, J. H. (2021). Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System. Molecules and Cells, 44(5), 310.

Cotton, R. N., Wegrecki, M., Cheng, T. Y., Chen, Y. L., Veerapen, N., Le Nours, J., ... & Moody, D. B. (2021). CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal of Experimental Medicine, 218(7), e20202699.

Cotton, R. N., Cheng, T. Y., Wegrecki, M., Le Nours, J., Orgill, D. P., Pomahac, B., ... & Moody, D. B. (2021). Human skin is colonized by T cells that recognize CD1a independently of lipid. The Journal of clinical investigation, 131(1).

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., ... & de Jong, A. (2020). Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Science immunology, 5(43).

Sánchez-Martínez, D., Baroni, M. L., Gutierrez-Agüera, F., Roca-Ho, H., Blanch-Lombarte, O., González-García, S., ... & Menéndez, P. (2019). Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 133(21), 2291-2304.

Taheri, M., Danesh, H., Bizhani, F., Bahari, G., Naderi, M., & Hashemi, M. (2019). Association between genetic variants in CD1A and CD1D genes and pulmonary tuberculosis in an Iranian population. Biomedical reports, 10(4), 259-265.

Rahman, M. I., Jahan, I., Khalid, M. M., Jahan, I., Ahammad, R. U., Nahar, S., & Islam, Z. (2018). CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population. Journal of neuroimmunology, 314, 8-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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