CD1a
CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1B.
Full Name
CD1a Molecule
Alternative Names
CD1a Molecule; T-Cell Surface Antigen T6/Leu-6; CD1A Antigen, A Polypeptide; HTa1 Thymocyte Antigen; CD1a Antigen; Epidermal Dendritic Cell Marker CD1a; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1a;
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Endosome membrane; Cell membrane; Membrane raft. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Topology
Extracellular: 17-300
Helical: 301-321
Cytoplasmic: 322-327
Helical: 301-321
Cytoplasmic: 322-327
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Anti-CD1a antibodies
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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HI149
Application*: F, IF
Target: CD1a
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: OKT-6
Application*: B, F, in vivo
Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 4H10
Application*: E, IH
Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT268
Application*: P, IF, IC
Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT282
Application*: WB, P, IF, IC, E
Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT283
Application*: WB, F, E
Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3385
Application*: WB, F
Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2653
Application*: WB, IH, IC
Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4057
Application*: IH, F
Target: CD1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4471
Application*: WB, IH, IC, F
Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC105
Application*: P, IF
Target: CD1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2287
Application*: WB, ELISA
Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: O10
Application*: WB, IF, IP, P
Target: CD1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey
Clone: NA1/34-HLK
Application*: F, IF
Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBT6
Application*: F, IF, WB, ELISA, P, IP
Target: CD1A
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: C1A/1506R
Application*: IH
Target: CD1A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 214A9.01
Application*: F, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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