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CD1a

CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1B.
Full Name
CD1a Molecule
Alternative Names
CD1a Molecule; T-Cell Surface Antigen T6/Leu-6; CD1A Antigen, A Polypeptide; HTa1 Thymocyte Antigen; CD1a Antigen; Epidermal Dendritic Cell Marker CD1a; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1a;
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Endosome membrane; Cell membrane; Membrane raft. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Topology
Extracellular: 17-300
Helical: 301-321
Cytoplasmic: 322-327
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Anti-CD1a antibodies

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Mouse Anti-CD1A Recombinant Antibody (HI149) (CBMAB-C1771-CQ)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HI149
Application*: F, IF
Datasheet SDS

Mouse Anti- CD1a Recombinant Antibody (OKT-6) (CBMAB-0918-LY)

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Target: CD1a
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: OKT-6
Application*: B, F, in vivo
In Vivo Assay Functional Assay
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT268) (V2LY-0625-LY3651)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT268
Application*: P, IF, IC
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT282) (V2LY-0625-LY3637)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT282
Application*: WB, P, IF, IC, E
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT283) (V2LY-0625-LY3636)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT283
Application*: WB, F, E
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT3385) (V2LY-0625-LY2546)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3385
Application*: WB, F
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT2653) (V2LY-0625-LY2543)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2653
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT4057) (V2LY-0625-LY1603)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4057
Application*: IH, F
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT4471) (V2LY-0625-LY1602)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4471
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (EC105) (V2LY-0624-LY105)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC105
Application*: P, IF
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBXC-2287) (CBMAB-C4030-CQ)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2287
Application*: WB, ELISA
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (O10) (CBMAB-C0962-CQ)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: O10
Application*: WB, IF, IP, P
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (NA1/34-HLK) (CBMAB-C0955-CQ)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey
Clone: NA1/34-HLK
Application*: F, IF
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (CBT6) (CBMAB-C0527-CQ)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBT6
Application*: F, IF, WB, ELISA, P, IP
Datasheet SDS

Rabbit Anti-CD1A Recombinant Antibody (C1A/1506R) (CBMAB-C0463-CQ)

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Target: CD1A
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: C1A/1506R
Application*: IH
Datasheet SDS

Mouse Anti-CD1A Recombinant Antibody (214A9.01) (CBMAB-C0628-LY)

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Target: CD1A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 214A9.01
Application*: F, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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