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Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672)


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Tested Data
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in ELISA
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in ELISA
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in WB
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in WB
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in WB
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in WB
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in FC
Mouse Anti-CD1D Recombinant Antibody (CBT3153) (V2LY-0625-LY1672) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3153
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD1D (AA: extra 20-301) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
912
UniProt ID
P15813
Alternative Names
CD1d Molecule; CD1D Antigen, D Polypeptide; CD1d Antigen; R3G1; HMC Class I Antigen-Like Glycoprotein CD1D; Antigen-Presenting Glycoprotein CD1d;
Function
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: UniProtKB
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Detection of bacterium Source: UniProtKB
Heterotypic cell-cell adhesion Source: BHF-UCL
Innate immune response Source: UniProtKB-KW
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Positive regulation of T cell proliferation Source: BHF-UCL
Regulation of immune response Source: Reactome
T cell selection Source: UniProtKB
Cellular Location
Lysosome membrane; Endoplasmic reticulum membrane; Endosome membrane; Cell membrane; Basolateral cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
Topology
Extracellular: 20-301
Helical: 302-322
Cytoplasmic: 323-335
More Infomation

Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., ... & Luckey, C. J. (2021). The lysophospholipid‐binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. Transfusion, 61(7), 2169-2178.

Lameris, R., Shahine, A., Pellicci, D. G., Uldrich, A. P., Gras, S., Le Nours, J., ... & van der Vliet, H. J. (2020). A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response. Nature Cancer, 1(11), 1054-1065.

Almeida, C. F., Sundararaj, S., Le Nours, J., Praveena, T., Cao, B., Burugupalli, S., ... & Rossjohn, J. (2019). Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nature communications, 10(1), 1-14.

Qin, Y., Oh, S., Lim, S., Shin, J. H., Yoon, M. S., & Park, S. H. (2019). Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells. Experimental & molecular medicine, 51(10), 1-9.

Iwamura, C., & Nakayama, T. (2018). Role of CD1d-and MR1-restricted T cells in asthma. Frontiers in immunology, 9, 1942.

King, L. A., Lameris, R., de Gruijl, T. D., & van der Vliet, H. J. (2018). CD1d-invariant natural killer T cell-based cancer immunotherapy: α-Galactosylceramide and beyond. Frontiers in immunology, 9, 1519.

Huh, J. Y., Park, Y. J., & Kim, J. B. (2018). Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity. Adipocyte, 7(2), 129-136.

Brutkiewicz, R. R., Yunes-Medina, L., & Liu, J. (2018). Immune evasion of the CD1d/NKT cell axis. Current opinion in immunology, 52, 87-92.

Rizvi, Z. A., Puri, N., & Saxena, R. K. (2018). Evidence of CD1d pathway of lipid antigen presentation in mouse primary lung epithelial cells and its up-regulation upon Mycobacterium bovis BCG infection. Plos one, 13(12), e0210116.

Brennan, P. J., Cheng, T. Y., Pellicci, D. G., Watts, G. F., Veerapen, N., Young, D. C., ... & Moody, D. B. (2017). Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface. Proceedings of the National Academy of Sciences, 114(31), 8348-8353.

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For research use only. Not intended for any clinical use.

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