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Rabbit Anti-CD200R1 Recombinant Antibody (118) (CBMAB-C2470-LY)

This product is antibody recognizes CD200R1. The antibody 118 immunoassay techniques such as: ELISA.
See all CD200R1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
118
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant human CD200R1 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD200 Receptor 1
Introduction
CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

An important paralog of this gene is CD200R1L.
Entrez Gene ID
UniProt ID
Alternative Names
CD200 Receptor 1; Cell Surface Glycoprotein OX2 Receptor 1; CD200 Cell Surface Glycoprotein Receptor; MOX2 Receptor; CD200R; MOX2R;
Function
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Biological Process
Heterotypic cell-cell adhesion Source: ARUK-UCL
Intracellular signal transduction Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Signal transduction Source: ARUK-UCL
Viral process Source: UniProtKB-KW
Cellular Location
Isoform 1&4: Cell membrane
Isoform 2&3: Secreted
Topology
Extracellular: 29-243
Helical: 244-264
Cytoplasmic: 265-325
PTM
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Rabaneda-Lombarte, N., Serratosa, J., Bové, J., Vila, M., Saura, J., & Solà, C. (2021). The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease. Journal of Neuroinflammation, 18(1), 1-21.

Erin, N., Dilmaç, S., Curry, A., Duymuş, Ö., Tanriover, G., Prodeus, A., ... & Gorczynski, R. M. (2020). Cd200 mimetic aptamer peg-m49 markedly increases the therapeutic effects of pegylated liposomal doxorubicin in a mouse model of metastatic breast carcinoma: An effect independent of cd200 receptor 1. Cancer Immunology, Immunotherapy, 69(1), 103-114.

Rabaneda-Lombarte, N., Blasco-Agell, L., Serratosa, J., Ferigle, L., Saura, J., & Solà, C. (2020). Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells: involvement of the CD200-CD200R1 ligand-receptor pair. Scientific reports, 10(1), 1-19.

Yoshimura, K., Suzuki, Y., Inoue, Y., Tsuchiya, K., Karayama, M., Iwashita, Y., ... & Suda, T. (2020). CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. OncoImmunology, 9(1), 1746554.

Ritzel, R. M., Al Mamun, A., Crapser, J., Verma, R., Patel, A. R., Knight, B. E., ... & McCullough, L. D. (2019). CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke. Journal of neuroinflammation, 16(1), 1-16.

Feng, Z., Ye, L., Klebe, D., Ding, Y., Guo, Z. N., Flores, J. J., ... & Zhang, J. H. (2019). Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage. Journal of Cerebral Blood Flow & Metabolism, 39(1), 97-107.

Oweira, H., Khajeh, E., Mohammadi, S., Ghamarnejad, O., Daniel, V., Schnitzler, P., ... & Sadeghi, M. (2019). Pre-transplant CD200 and CD200R1 concentrations are associated with post-transplant events in kidney transplant recipients. Medicine, 98(37).

Liu, C., Shen, Y., Tang, Y., & Gu, Y. (2018). The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation. Journal of Inflammation, 15(1), 1-10.

Lago, N., Pannunzio, B., Amo-Aparicio, J., López-Vales, R., & Peluffo, H. (2018). CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1. Brain, behavior, and immunity, 73, 416-426.

Huang, R., Lan, Q., Chen, L., Zhong, H., Cui, L., Jiang, L., ... & Xu, F. (2018). CD200Fc attenuates retinal glial responses and RGCs apoptosis after optic nerve crush by modulating CD200/CD200R1 interaction. Journal of Molecular Neuroscience, 64(2), 200-210.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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