CD200R1

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.
Full Name
CD200 Receptor 1
Function
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Biological Process
Heterotypic cell-cell adhesion Source: ARUK-UCL
Intracellular signal transduction Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Signal transduction Source: ARUK-UCL
Viral process Source: UniProtKB-KW
Cellular Location
Isoform 1&4: Cell membrane
Isoform 2&3: Secreted
Topology
Extracellular: 29-243
Helical: 244-264
Cytoplasmic: 265-325
PTM
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
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Anti-CD200R1 antibodies

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Mouse Anti-CD200R1 Recombinant Antibody (OX-102) (CBMAB-1331-CN)

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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Mouse
Clone: OX-102
Application*: F, IF
Datasheet SDS

Mouse Anti-CD200R1 Recombinant Antibody (OX108) (CBMAB-C0968-CQ)

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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: OX108
Application*: F
Datasheet SDS

Mouse Anti-CD200R1 Recombinant Antibody (CBFYC-1149) (CBMAB-C1207-FY)

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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1149
Application*: F
Datasheet SDS

Mouse Anti-CD200R1 Recombinant Antibody (CBFYC-1148) (CBMAB-C1206-FY)

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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: CBFYC-1148
Application*: E
Datasheet SDS

Rabbit Anti-CD200R1 Recombinant Antibody (118) (CBMAB-C2470-LY)

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Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 118
Application*: E
Datasheet SDS

Rabbit Anti-CD200R1 Recombinant Antibody (019) (CBMAB-C1645-LY)

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Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 019
Application*: E
Datasheet SDS

Rabbit Anti-CD200R1 Recombinant Antibody (181) (CBMAB-C0440-LY)

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Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 181
Application*: F
Datasheet SDS

Mouse Anti-CD200R1 Recombinant Antibody (04) (CBMAB-C0072-LY)

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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 04
Application*: E, F
Datasheet SDS

Rat Anti-CD200R1 Recombinant Antibody (OX-110) (CBMAB-1332-CN)

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Target: CD200R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-110
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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