CD200R1
CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.
Full Name
CD200 Receptor 1
Function
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Biological Process
Heterotypic cell-cell adhesion Source: ARUK-UCL
Intracellular signal transduction Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Signal transduction Source: ARUK-UCL
Viral process Source: UniProtKB-KW
Intracellular signal transduction Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Signal transduction Source: ARUK-UCL
Viral process Source: UniProtKB-KW
Cellular Location
Isoform 1&4: Cell membrane
Isoform 2&3: Secreted
Isoform 2&3: Secreted
Topology
Extracellular: 29-243
Helical: 244-264
Cytoplasmic: 265-325
Helical: 244-264
Cytoplasmic: 265-325
PTM
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
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Anti-CD200R1 antibodies
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Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Mouse
Clone: OX-102
Application*: F, IF
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-238
Tag: His Tag
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-238
Tag: His & hFc Tag
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-266
Tag: His Tag
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-266
Tag: His Tag
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-266
Tag: His & hFc Tag
Target: CD200R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-267
Tag: His Tag
Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: OX108
Application*: F
Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1149
Application*: F
Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: CBFYC-1148
Application*: E
Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 118
Application*: E
Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 019
Application*: E
Target: CD200R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 181
Application*: F
Target: CD200R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 04
Application*: E, F
Target: CD200R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-110
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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