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Armenian Hamster Anti-CD209 Recombinant Antibody (22D1) (CBMAB-0973-LY)


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Summary

Host Animal
Armenian Hamster
Specificity
Mouse
Clone
22D1
Antibody Isotype
IgG, κ
Application
Blocking, FC, WB, IHC, in vivo

Basic Information

Immunogen
C-terminal peptide of mouse SIGN-R1.
Host Species
Armenian Hamster
Specificity
Mouse
Antibody Isotype
IgG, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Entrez Gene ID
69165
UniProt ID
Q8CJ91
More Infomation

Rahimi, N. (2021). C-type lectin CD209L/L-SIGN and CD209/DC-SIGN: cell adhesion molecules turned to pathogen recognition receptors. Biology, 10(1), 1.

Kakar, M. U., Matloob, M., Dai, R., Deng, Y., Ullah, K., Kakar, I. U., ... & Mehboob, M. Z. (2021). In silico screening and identification of deleterious missense SNPs along with their effects on CD-209 gene: An insight to CD-209 related-diseases. Plos one, 16(2), e0247249.

Amraei, R., Yin, W., Napoleon, M. A., Suder, E. L., Berrigan, J., Zhao, Q., ... & Rahimi, N. (2021). CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2. ACS Central Science, 7(7), 1156-1165.

Xue, Y., Li, Q., Park, C. G., Klena, J. D., Anisimov, A. P., Sun, Z., ... & Chen, T. (2021). Proteus mirabilis Targets Atherosclerosis Plaques in Human Coronary Arteries via DC-SIGN (CD209). Frontiers in Immunology, 3351.

Njiri, O. A., Zhang, X., Zhang, Y., Wu, B., Jiang, L., Li, Q., ... & Chen, T. (2020). CD209 C-Type lectins promote host invasion, dissemination, and infection of toxoplasma gondii. Frontiers in immunology, 11, 656.

Deykin, A. V., Kubekina, M. V., Silaeva, Y. Y., Krivonogova, A. S., & Isaeva, A. G. (2020). Using CRISPR/Cas9 for generation the cd209 knockout is a way to get cattle breeds resistant to the bovine leukemia virus (BLV). In E3S Web of Conferences (Vol. 176, p. 01007). EDP Sciences.

He, Y. X., Ye, C. L., Zhang, P., Li, Q., Park, C. G., Yang, K., ... & Chen, T. (2019). Yersinia pseudotuberculosis exploits CD209 receptors for promoting host dissemination and infection. Infection and immunity, 87(1), e00654-18.

Pabalan, N., Chaisri, S., Tabunhan, S., Phumyen, A., Jarjanazi, H., & Steiner, T. S. (2018). Associations of DC-SIGN (CD209) promoter-336G/A polymorphism (rs4804803) with dengue infection: A systematic review and meta-analysis. Acta tropica, 177, 186-193.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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