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CD209

CD209 (CD209 Molecule) is a Protein Coding gene. Diseases associated with CD209 include Dengue Virus and Human Immunodeficiency Virus Type 1. Among its related pathways are CLEC7A (Dectin-1) signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and mannose binding. An important paralog of this gene is CLEC4M.
Full Name
CD209 Molecule
Function
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.
(Microbial infection) Acts as an attachment receptor for HCV.
(Microbial infection) Acts as an attachment receptor for Dengue virus.
(Microbial infection) Acts as an attachment receptor for Measles virus.
(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.
(Microbial infection) Acts as an attachment receptor for Influenzavirus A.
(Microbial infection) Acts as an attachment receptor for SARS-CoV.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn.
(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.
(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498).
Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).
Biological Process
Adaptive immune response Source: Reactome
Antigen processing and presentation Source: UniProtKB
B cell adhesion Source: UniProtKB
Cell-cell recognition Source: UniProtKB
Endocytosis Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Intracellular signal transduction Source: UniProtKB
Intracellular transport of virus Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Modulation by virus of host process Source: UniProtKB
Peptide antigen transport Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of viral life cycle Source: FlyBase
Regulation of T cell proliferation Source: MGI
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Viral entry into host cell Source: FlyBase
Viral genome replication Source: UniProtKB
Virion attachment to host cell Source: UniProtKB
Cellular Location
Isoform 1&2&3&4&5: Cell membrane
Isoform 6&7&8&9&10&11&12: Secreted
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-404

Anti-CD209 antibodies

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Target: CD209
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0191
Application*: E, IP
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0189
Application*: F, IF
Target: CD209
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 13A172
Application*: IH
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MMD3
Application*: F
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8B6
Application*: E, IH, WB
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Dog
Clone: 102E11.06
Application*: F, IH, P, C
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 102F10.04
Application*: F, C, IC, IF
Target: CD209
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 103G2.07
Application*: F, IH, P, C
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 108C7.01
Application*: F, FN
Target: CD209
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 109H12.03
Application*: F, C, IC, IF, P
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 111H2.02
Application*: F, IH
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 120507
Application*: F, I
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D7
Application*: E, P, WB
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6G53
Application*: IH
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G178
Application*: F
Target: CD209
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C209/1781
Application*: F, IC, IF, P
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DCN47.5
Application*: F, FN
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UW60.1
Application*: IC, F
Target: CD209
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: h209
Application*: F
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6G52
Application*: IH
Target: CD209
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B10
Application*: E, IP
Target: CD209
Host: Mouse
Specificity: Human
Clone: CBYY-C1260
Application*: WB, IH
Target: CD209
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 9E9A8
Application*: IF, WB
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-XB002
Application*: F, IH, WB
Target: CD209
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L172
Application*: FC, IH, N
Target: CD209
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7F5C
Application*: WB, IP, IF (IC), F
Target: CD209
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb260
Application*: FC, FuncS
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP386
Application*: ELISA, IHC, WB
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP387
Application*: ELISA, IHC, WB
Target: CD209
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: A037
Application*: FC, IHC, IP
Target: CD209
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2626
Application*: E, WB, P
Target: CD209
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0899
Application*: F
Target: CD209
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1157
Application*: WB, E
Target: CD209
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1156
Application*: ED
Target: CD209
Host: Mouse
Specificity: Human
Clone: CBFYC-1155
Application*: EC
Target: CD209
Host: Rat
Antibody Isotype: IgM
Specificity: Mouse
Clone: ER-TR9
Application*: F, FN, C, P
Target: CD209
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 5H10
Application*: WB, IP, IC, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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