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Mouse Anti-CD37 Recombinant Antibody (CBT2629) (V2LY-0625-LY2249)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT2629
Antibody Isotype
IgG1
Application
ICC

Basic Information

Immunogen
Purified recombinant fragment of CD37 expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD37 Molecule
Entrez Gene ID
951
UniProt ID
P11049
Cellular Location
Membrane
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-59
Helical: 60-74
Cytoplasmic: 75-85
Helical: 86-111
Extracellular: 112-241
Helical: 242-266
Cytoplasmic: 267-281
More Infomation

Okuno, S., Adachi, Y., Terakura, S., Julamanee, J., Sakai, T., Umemura, K., ... & Kiyoi, H. (2021). Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells. The Journal of Immunology.

van der Horst, H. J., Oostindie, S. C., Cillessen, S. A., Gelderloos, A. T., Overdijk, M. B., Nijhof, I. S., ... & Mutis, T. (2021). Potent preclinical efficacy of DuoHexaBody-CD37 in B-cell malignancies. Hemasphere, 5(1).

Yan, X., Zhou, Q., Zhu, H., Liu, W., Xu, H., Yin, W., ... & Ren, C. (2021). The clinical features, prognostic significance, and immune heterogeneity of CD37 in diffuse gliomas. Iscience, 24(11), 103249.

Oostindie, S. C., van der Horst, H. J., Kil, L. P., Strumane, K., Overdijk, M. B., van den Brink, E. N., ... & Breij, E. C. (2020). DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies. Blood cancer journal, 10(3), 1-13.

Bobrowicz, M., Kubacz, M., Slusarczyk, A., & Winiarska, M. (2020). CD37 in B cell derived tumors—more than just a docking point for monoclonal antibodies. International Journal of Molecular Sciences, 21(24), 9531.

Zhang, Q., Han, Q., Zi, J., Song, C., & Ge, Z. (2020). CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia. Bioscience reports, 40(5), BSR20200008.

Malenge, M. M. (2020). Combination of anti-CD37 radioimmunotherapy with anti-CD20 immunotherapy and small molecule inhibitors to improve therapy of non-Hodgkin lymphoma.

Oostindie, S. C., Van Der Horst, H. J., Lindorfer, M. A., Cook, E. M., Tupitza, J. C., Zent, C. S., ... & Taylor, R. P. (2019). CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering. haematologica, 104(9), 1841.

Payandeh, Z., Noori, E., Khalesi, B., Mard-Soltani, M., Abdolalizadeh, J., & Khalili, S. (2018). Anti-CD37 targeted immunotherapy of B-Cell malignancies. Biotechnology letters, 40(11), 1459-1466.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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