Mouse Anti-CD38 Recombinant Antibody (AG25) (V2LY-0524-LY24)

Name: Mouse Anti-CD38 Recombinant Antibody (AG25)
SKU: V2LY-0524-LY24
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

AG25

Application

Host Species

Mouse

Specificity

Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

< 1.0 EU/mg as determined by the LAL method

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

5 mg/ml

Purity

>95% by SDS Page

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD38 Molecule

Entrez Gene ID

714399

UniProt ID

Q5VAN0

Alternative Names

CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase;

Function

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Biological Process

Apoptotic signaling pathway Source: ProtInc
Artery smooth muscle contraction Source: Ensembl
B cell receptor signaling pathway Source: UniProtKB
Female pregnancy Source: Ensembl
Long-term synaptic depression Source: Ensembl
NAD metabolic process Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of bone resorption Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of cell growth Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of vasoconstriction Source: Ensembl
Response to drug Source: UniProtKB
Response to estradiol Source: Ensembl
Response to hydroperoxide Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to progesterone Source: Ensembl
Response to retinoic acid Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Membrane

Topology

Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-300

García-Guerrero, E., Götz, R., Doose, S., Sauer, M., Rodríguez-Gil, A., Nerreter, T., ... & Danhof, S. (2021). Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia, 35(1), 201-214.

Piedra-Quintero, Z. L., Wilson, Z., Nava, P., & Guerau-de-Arellano, M. (2020). CD38: an immunomodulatory molecule in inflammation and autoimmunity. Frontiers in immunology, 11, 3111.

Katsuyama, E., Suarez-Fueyo, A., Bradley, S. J., Mizui, M., Marin, A. V., Mulki, L., ... & Tsokos, G. C. (2020). The CD38/NAD/SIRTUIN1/EZH2 axis mitigates cytotoxic CD8 T cell function and identifies patients with SLE prone to infections. Cell reports, 30(1), 112-123.

Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., ... & Lopatina, O. (2020). CD38, CD157, and RAGE as molecular determinants for social behavior. Cells, 9(1), 62.

Glaría, E., & Valledor, A. F. (2020). Roles of CD38 in the Immune Response to Infection. Cells, 9(1), 228.

Ning, L., Shan, G., Sun, Z., Zhang, F., Xu, C., Lou, X., ... & Xu, G. (2019). Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease. BioMed research international, 2019.

Morandi, F., Airoldi, I., Marimpietri, D., Bracci, C., Faini, A. C., & Gramignoli, R. (2019). CD38, a receptor with multifunctional activities: from modulatory functions on regulatory cell subsets and extracellular vesicles, to a target for therapeutic strategies. Cells, 8(12), 1527.

Malavasi, F., & Faini, A. C. (2019). Mechanism of action of a new anti-CD38 antibody: enhancing myeloma immunotherapy. Clinical Cancer Research, 25(10), 2946-2948.

van de Donk, N. W., Richardson, P. G., & Malavasi, F. (2018). CD38 antibodies in multiple myeloma: back to the future. Blood, The Journal of the American Society of Hematology, 131(1), 13-29.

Van De Donk, N. W., & Usmani, S. Z. (2018). CD38 antibodies in multiple myeloma: mechanisms of action and modes of resistance. Frontiers in immunology, 9, 2134.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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