Sign in or Register   Sign in or Register
  |  

Rat Anti-CD5 Recombinant Antibody (CBXC-1387) (CBMAB-C2616-CQ)

This product is a rat antibody that recognizes CD5. The antibody CBXC-1387 can be used for immunoassay techniques such as: FC.
See all CD5 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1387
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
CBA mouse thymocytes
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD5 Molecule
Introduction
CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymus Cancer and Richter's Syndrome. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways. Gene Ontology (GO) annotations related to this gene include receptor activity and scavenger receptor activity.
Entrez Gene ID
UniProt ID
Alternative Names
CD5 Molecule; Lymphocyte Antigen T1/Leu-1; CD5 Antigen (P56-62); LEU1; T-Cell Surface Glycoprotein CD5; CD5 Antigen; T1;
Function
May act as a receptor in regulating T-cell proliferation.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Cell recognition Source: UniProtKB
T cell costimulation Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 25-372
Helical: 373-402
Cytoplasmic: 403-495
PTM
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

Velasco-de-Andrés, M., Català, C., Casadó-Llombart, S., Simões, I., Zaragoza, O., Carreras, E., & Lozano, F. (2021). The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection. Cellular & molecular immunology, 18(2), 498-500.

Dai, Z., Mu, W., Zhao, Y., Jia, X., Liu, J., Wei, Q., ... & Zhou, J. (2021). The rational development of CD5-targeting biepitopic CARs with fully human heavy-chain-only antigen recognition domains. Molecular Therapy, 29(9), 2707-2722.

Matson, C. A., Choi, S., Livak, F., Zhao, B., Mitra, A., Love, P. E., & Singh, N. J. (2020). CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation. Proceedings of the National Academy of Sciences, 117(25), 14342-14353.

Velasco-de Andrés, M., Casadó-Llombart, S., Català, C., Leyton-Pereira, A., Lozano, F., & Aranda, F. (2020). Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents. Cells, 9(12), 2589.

Blaize, G., Daniels-Treffandier, H., Aloulou, M., Rouquié, N., Yang, C., Marcellin, M., ... & Lesourne, R. (2020). CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens. Proceedings of the National Academy of Sciences, 117(23), 12969-12979.

Alotaibi, F., Rytelewski, M., Figueredo, R., Zareardalan, R., Zhang, M., Ferguson, P. J., ... & Koropatnick, J. (2020). CD5 blockade enhances ex vivo CD8+ T cell activation and tumour cell cytotoxicity. European journal of immunology, 50(5), 695-704.

Burgueño‐Bucio, E., Mier‐Aguilar, C. A., & Soldevila, G. (2019). The multiple faces of CD5. Journal of leukocyte biology, 105(5), 891-904.

Zhao, P., Li, L., Zhou, S., Qiu, L., Qian, Z., Liu, X., ... & Zhang, H. (2019). CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B‐cell lymphoma. Hematological oncology, 37(4), 360-367.

Voisinne, G., Gonzalez de Peredo, A., & Roncagalli, R. (2018). CD5, an undercover regulator of TCR signaling. Frontiers in immunology, 9, 2900.

Abós, B., Bird, S., Granja, A. G., Morel, E., Bayona, J. A. M., Barreda, D. R., & Tafalla, C. (2018). Identification of the first teleost CD5 molecule: additional evidence on phenotypical and functional similarities between fish IgM+ B cells and mammalian B1 cells. The Journal of Immunology, 201(2), 465-480.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rat Anti-CD5 Recombinant Antibody (CBXC-1387)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare