Mouse Anti-CD53 Recombinant Antibody (CBYY-C1499) (CBMAB-C2937-YY)

Name: Mouse Anti-CD53 Recombinant Antibody (CBYY-C1499)
SKU: CBMAB-C2937-YY
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C1499

Antibody Isotype

IgG1

Application

FC, WB, IF, IHC

Basic Information

Immunogen

Human CD53.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	1:10-1:25

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

CD53 Molecule

Entrez Gene ID

963

UniProt ID

P19397

Function

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Biological Process

Neutrophil degranulation Source: Reactome
Positive regulation of myoblast fusion Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane; Cell junction; Membrane. Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.

Topology

Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-54
Helical: 55-69
Cytoplasmic: 70-80
Helical: 81-106
Extracellular: 107-181
Helical: 182-206
Cytoplasmic: 207-219

More Infomation

References

Yeung, L., Gottschalk, T. A., Hall, P., Tsantikos, E., Gallagher, R. H., Kitching, A. R., ... & Hickey, M. J. (2021). Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn‐deficient mice. Immunology and Cell Biology.

Greenberg, Z. J. (2021). The Role of CD53 in Hematopoietic Development, Stress, and Malignancy.

Dunlock, V. E. (2020). Tetraspanin CD53: an overlooked regulator of immune cell function. Medical Microbiology and Immunology, 209, 545-552.

Demaria, M. C., Yeung, L., Peeters, R., Wee, J. L., Mihaljcic, M., Jones, E. L., ... & Wright, M. D. (2020). Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression. Iscience, 23(5), 101104.

Yeung, L., Anderson, J. M., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., ... & Hickey, M. J. (2020). Leukocyte Tetraspanin CD53 Restrains α3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. The Journal of Immunology, 205(2), 521-532.

Omae, Y., Toyo-Oka, L., Yanai, H., Nedsuwan, S., Wattanapokayakit, S., Satproedprai, N., ... & Mahasirimongkol, S. (2017). Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis. Journal of human genetics, 62(12), 1015-1022.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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