CD53
CD53 (CD53 Molecule) is a Protein Coding gene. Diseases associated with CD53 include Intestinal Tuberculosis and Gastrointestinal Tuberculosis. Among its related pathways are Innate Immune System. An important paralog of this gene is TSPAN9.
Full Name
CD53 Molecule
Function
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Biological Process
Neutrophil degranulation Source: Reactome
Positive regulation of myoblast fusion Source: UniProtKB
Signal transduction Source: ProtInc
Positive regulation of myoblast fusion Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane; Cell junction; Membrane. Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
Topology
Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-54
Helical: 55-69
Cytoplasmic: 70-80
Helical: 81-106
Extracellular: 107-181
Helical: 182-206
Cytoplasmic: 207-219
Helical: 12-32
Extracellular: 33-54
Helical: 55-69
Cytoplasmic: 70-80
Helical: 81-106
Extracellular: 107-181
Helical: 182-206
Cytoplasmic: 207-219
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Anti-CD53 antibodies
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Target: CD53
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0742
Application*: F
Target: CD53
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3288
Application*: IH, F
Target: CD53
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3720
Application*: WB, IH, F
Target: CD53
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Mouse
Clone: OX-44
Application*: F, IP, IF, P
Target: CD53
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2972
Application*: F, IF
Target: CD53
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1499
Application*: F, WB, IF, IH
Target: CD53
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0132
Application*: IP, IF, F
Target: CD53
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0320
Application*: IF, P, IP, WB, E
Target: CD53
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 13
Application*: E
Target: CD53
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: 104
Application*: E, WB, IP
Target: CD53
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 004
Application*: WB, IP
Target: CD53
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 63-5A3
Application*: F, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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