Rabbit Anti-CD55 Recombinant Antibody (084) (CBMAB-C1874-LY)

Name: Rabbit Anti-CD55 Recombinant Antibody (084)
SKU: CBMAB-C1874-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

084

Application

ELISA

Immunogen

Recombinant Mouse CD55 / DAF protein.

Host Species

Rabbit

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD55 molecule (Cromer blood group)

Introduction

CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy and Blood Group, Cromer System. Among its related pathways are Creation of C4 and C2 activators and Transport to the Golgi and subsequent modification.
Gene Ontology (GO) annotations related to this gene include lipid binding and virus receptor activity.
An important paralog of this gene is C4BPA.

Entrez Gene ID

13136

UniProt ID

Q61475

Research Area

Immunology

Function

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274).
Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).
(Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5.
(Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).
(Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.

Biological Process

Complement activation, classical pathway
Innate immune response
Negative regulation of complement activation
Positive regulation of CD4-positive, alpha-beta T cell activation
Positive regulation of CD4-positive, alpha-beta T cell proliferation
Positive regulation of cytosolic calcium ion concentration
Positive regulation of T cell cytokine production
Regulation of complement activation
Regulation of complement-dependent cytotoxicity
Regulation of lipopolysaccharide-mediated signaling pathway
Respiratory burst

Cellular Location

Isoform 1
Cell membrane ; Single-pass type I membrane protein
Isoform 2
Cell membrane ; Lipid-anchor, GPI-anchor
Isoform 3
Secreted
Isoform 4
Secreted
Isoform 5
Secreted
Isoform 6
Cell membrane
Isoform 7
Cell membrane

Involvement in disease

Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE):
An autosomal recessive disease characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease. Patients' T lymphocytes show increased complement activation causing surface deposition of complement and the generation of soluble C5a.

PTM

The Ser/Thr-rich domain is heavily O-glycosylated.

Moreira, M., Ruggiero, A., Iaccarino, E., Barra, G., Sandomenico, A., Ruvo, M., & Berisio, R. (2021). A structure-based approach for the development of a bicyclic peptide acting as a miniaturized anti-CD55 antibody. International Journal of Biological Macromolecules, 182, 1455-1462.

Niu, M., Xu, S., Yang, J., Yao, D., Li, N., Yan, J., ... & Song, G. (2021). Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs. Journal of Biological Chemistry, 296.

Lin, W. D., Fan, T. C., Hung, J. T., Yeo, H. L., Wang, S. H., Kuo, C. W., ... & Alice, L. Y. (2020). Sialylation of CD55 by ST3GAL1 facilitates immune evasion in cancer. Cancer Immunology Research.

Pérez‐Alós, L., Bayarri‐Olmos, R., Skjoedt, M. O., & Garred, P. (2019). Combining MAP‐1: CD35 or MAP‐1: CD55 fusion proteins with pattern‐recognition molecules as novel targeted modulators of the complement cascade. The FASEB Journal, 33(11), 12723-12734.

Musarrat, T. (2019). Modulation of IL-10 production by CD3/CD55 induced Type 1 regulatory (Tr1) T-cells (Doctoral dissertation, University of Nottingham).

Loniewska‐Lwowska, A., Koza, K., Mendek‐Czajkowska, E., Wieszczy, P., Adamowicz‐Salach, A., Branicka, K., ... & Fabijanska‐Mitek, J. (2018). Diminished presentation of complement regulatory protein CD 55 on red blood cells from patients with hereditary haemolytic anaemias. International journal of laboratory hematology, 40(2), 128-135.

Dho, S. H., Lim, J. C., & Kim, L. K. (2018). Beyond the role of CD55 as a complement component. Immune network, 18(1).

Li, G., Yin, Q., Ji, H., Wang, Y., Liu, H., Jiang, L., ... & Li, B. (2018). A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells. Drug design, development and therapy, 12, 3899.

Ozen, A., Comrie, W. A., Ardy, R. C., Domínguez Conde, C., Dalgic, B., Beser, Ö. F., ... & Lenardo, M. J. (2017). CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis. New England Journal of Medicine, 377(1), 52-61.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CD55 Matched Antibody Pair (229) (CAT#: APMAB-229LY)

CD55 Matched Antibody Pair (230) (CAT#: APMAB-230LY)

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CD55 Matched Antibody Pair (229) (CAT#: APMAB-229LY)

CD55 Matched Antibody Pair (230) (CAT#: APMAB-230LY)

Isotype control

For research use only. Not intended for any clinical use.

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