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Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607)


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Tested Data
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in FC
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in FC
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in IHC
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in IHC
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in WB
Mouse Anti-CD69 Recombinant Antibody (CBT314) (V2LY-0625-LY3607) in WB

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT314
Antibody Isotype
IgG
Application
WB, IHC-P, IF, FC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human CD69 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
FC1:200-1:400
IHC1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD69 Molecule
Entrez Gene ID
969
UniProt ID
Q07108
Function
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Cellular Location
Membrane
Topology
Cytoplasmic: 1-40
Helical: 41-61
Extracellular: 62-199
PTM
Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.
More Infomation

Gorabi, A. M., Hajighasemi, S., Kiaie, N., Hayat, S. M. G., Jamialahmadi, T., Johnston, T. P., & Sahebkar, A. (2020). The pivotal role of CD69 in autoimmunity. Journal of autoimmunity, 111, 102453.

Notario, L., Redondo-Antón, J., Alari-Pahissa, E., Albentosa, A., Leiva, M., Lopez, D., ... & Lauzurica, P. (2019). CD69 targeting enhances anti-vaccinia virus immunity. Journal of virology, 93(19), e00553-19.

Kimura, M. Y., Koyama-Nasu, R., Yagi, R., & Nakayama, T. (2019, May). A new therapeutic target: the CD69-Myl9 system in immune responses. In Seminars in immunopathology (Vol. 41, No. 3).

Walsh, D. A., Da Silva, H. B., Beura, L. K., Peng, C., Hamilton, S. E., Masopust, D., & Jameson, S. C. (2019). The functional requirement for CD69 in establishment of resident memory CD8+ T cells varies with tissue location. The Journal of Immunology, 203(4), 946-955.

Brait, V. H., Miró-Mur, F., Pérez-de-Puig, I., Notario, L., Hurtado, B., Pedragosa, J., ... & Planas, A. M. (2019). CD69 plays a beneficial role in ischemic stroke by dampening endothelial activation. Circulation research, 124(2), 279-291.

Mita, Y., Kimura, M. Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., ... & Nakayama, T. (2018). Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. International immunology, 30(12), 559-567.

Kimura, M. Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., ... & Nakayama, T. (2018). CD69 prevents PLZF hi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nature communications, 9(1), 1-12.

Cibrián, D., & Sánchez‐Madrid, F. (2017). CD69: from activation marker to metabolic gatekeeper. European journal of immunology, 47(6), 946-953.

Yong, Y. K., Tan, H. Y., Saeidi, A., Rosmawati, M., Atiya, N., Ansari, A. W., ... & Shankar, E. M. (2017). Decrease of CD69 levels on TCR Vα7. 2+ CD4+ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients. Innate immunity, 23(5), 459-467.

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For research use only. Not intended for any clinical use.

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