Mouse Anti-CD79A Recombinant Antibody (JCB117) (CBMAB-C0749-CQ)

Name: Mouse Anti-CD79A Recombinant Antibody (JCB117)
SKU: CBMAB-C0749-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

JCB117

Application

WB, IF, IP, IHC-P

Immunogen

Amino acids 202-216 of CD79A of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD79a Molecule

Introduction

CD79A (CD79a Molecule) is a Protein Coding gene. Diseases associated with CD79A include Agammaglobulinemia 3, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.

Entrez Gene ID

973

UniProt ID

P11912

Alternative Names

CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; CD79A Antigen (Immunoglobulin-Associated Alpha); CD79a Molecule, Immunoglobulin-Associated Alpha; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha;

Function

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Biological Process

Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB

Cellular Location

Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Involvement in disease

Agammaglobulinemia 3, autosomal recessive (AGM3): The disease is caused by variants affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein. A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Topology

Extracellular: 33-143
Helical: 144-165
Cytoplasmic: 166-226

PTM

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).

Julamanee, J., Terakura, S., Umemura, K., Adachi, Y., Miyao, K., Okuno, S., ... & Kiyoi, H. (2021). Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival. Molecular Therapy.

Lenk, L., Carlet, M., Vogiatzi, F., Spory, L., Winterberg, D., Cousins, A., ... & Schewe, D. M. (2021). CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications biology, 4(1), 1-6.

Replicating, R. N. A. (2021). CD79A/CD40 endodomain enhances CAR-T persistence. Molecular Therapy, 29(9), 2627.

Berhili, A., Bensalah, M., ElMalki, J., Elyagoubi, A., & Seddik, R. (2021). Immunophenotypic challenges in diagnosis of CD79a negativity in a patient with B acute lymphoblastic leukemia harboring intrachromosomal amplification of chromosome 21: a case report. Journal of Medical Case Reports, 15(1), 1-6.

Mangogna, A., Cox, M. C., Ruco, L., Lopez, G., Belmonte, B., & Di Napoli, A. (2020). Rituximab plus chemotherapy provides no clinical benefit in a peripheral T-Cell lymphoma not otherwise specified with aberrant expression of CD20 and CD79a: a case report and review of the literature. Diagnostics, 10(6), 341.

Langereis, J. D., Henriet, S. S., Kuipers, S., Weemaes, C. M., van der Burg, M., de Jonge, M. I., & van der Flier, M. (2018). IgM augments complement bactericidal activity with serum from a patient with a novel CD79a mutation. Journal of clinical immunology, 38(2), 185-192.

Li, H., Li, Y., Zhang, X., Wang, Y., Zhang, W., Wu, X., & Wang, Z. (2017). Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus). Fish physiology and biochemistry, 43(6), 1571-1585.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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