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Rabbit Anti-CDC16 (Phosphorylated S560) Polyclonal Antibody (PTM-CBPAB-0445YC) (PTM-CBPAB-0445YC)

Provided herein is a Rabbit polyclonal antibody against Cell Division Cycle 16. The antibody can be used for immunoassay techniques, such as WB, IHC-P, ELISA.
See all CDC16 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application
WB, IHC-P, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Liquid in 10 mM PBS, pH 7.4 with 10 mg/ml BSA, 0.03% proclin 300 and 25% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle 16
Introduction
CDC16 (Cell Division Cycle 16) is a Protein Coding gene. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex.
Entrez Gene ID
Human8881
Mouse69957
Rat290875
UniProt ID
HumanQ13042
MouseQ8R349
RatQ4V884
Alternative Names
Cell Division Cycle 16; Anaphase-Promoting Complex, Subunit 6; Cyclosome Subunit 6; CDC16Hs; ANAPC6; APC6; CDC16 (Cell Division Cycle 16, S. Cerevisiae, Homolog); CDC16 Cell Division Cycle 16 Homolog (S. Cerevisiae);
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: GO_Central
Cell division Source: GO_Central
Metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
Positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
Protein K11-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of exit from mitosis Source: Reactome
Regulation of mitotic cell cycle phase transition Source: Reactome
Ubiquitin-dependent protein catabolic process Source: Reactome
Cellular Location
Centrosome; Spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
PTM
Phosphorylated. Phosphorylation on Ser-560 oCcurs specifically during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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