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Rabbit Anti-CDC42BPA Recombinant Antibody (EG571) (CBMAB-EN690-LY)

The product is antibody recognizes CDC42BPA. The antibody EG571 immunoassay techniques such as: WB: 1:500~1:3000 ELISA: 1:40000.
See all CDC42BPA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG571
Antibody Isotype
IgG
Application
WB: 1:500~1:3000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from Internal of human MRCKa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CDC42 Binding Protein Kinase Alpha
Introduction
CDC42BPA (CDC42 Binding Protein Kinase Alpha) is a Protein Coding gene. Diseases associated with CDC42BPA include Myotonic Dystrophy. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G-protein signaling RAC1 in cellular process. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is CDC42BPB.
Entrez Gene ID
Human8476
Mouse226751
Rat114116
UniProt ID
HumanQ5VT25
MouseQ3UU96
RatO54874
Alternative Names
CDC42 Binding Protein Kinase Alpha; Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha; Myotonic Dystrophy Protein Kinase-Like Alpha; DMPK-Like Alpha; EC 2.7.11.1; MRCK Alpha; Ser-Thr Protein Kinase Related To The Myotonic Dystrophy Protein Kinase; Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha; Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase; CDC42-Binding Protein Kinase Alpha (DMPK-Like); CDC42 Binding Protein Kinase Alpha (DMPK-Like);
Function
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543).
Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715).
In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160).
Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775).
May play a role in TFRC-mediated iron uptake (PubMed:20188707).
In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624).
Biological Process
Actin cytoskeleton reorganization Source: UniProtKB
Actomyosin structure organization Source: UniProtKB
Cell migration Source: UniProtKB
Intracellular signal transduction Source: InterPro
Peptidyl-threonine phosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Cellular Location
Cytoplasm; Lamellipodium. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner.
PTM
Proteolytically cleaved by caspases upon apoptosis induction. The cleavage at Asp-478 by CASP3 increases its kinase activity (in vitro).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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