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Mouse Anti-CDC45 Recombinant Antibody (2135C1a) (CBMAB-C0618-LY)

This product is antibody recognizes CDC45. The antibody 2135C1a immunoassay techniques such as: DB, WB.
See all CDC45 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2135C1a
Antibody Isotype
IgG1
Application
DB, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Division Cycle 45
Introduction
CDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include Meier-Gorlin Syndrome 7 and Meier-Gorlin Syndrome 1. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include chromatin binding and DNA replication origin binding.
Entrez Gene ID
8318
UniProt ID
O75419
Alternative Names
Cell Division Cycle 45; Human CDC45; PORC-PI-1; CDC45L2; CDC45L; CDC45 (Cell Division Cycle 45, S.Cerevisiae, Homolog)-Like; CDC45 Cell Division Cycle 45-Like (S. Cerevisiae); Cell Division Cycle 45 Homolog (S. Cerevisiae);
Function
Required for initiation of chromosomal DNA replication.
Biological Process
DNA replication Source: Reactome
DNA replication checkpoint Source: ProtInc
DNA replication initiation Source: GO_Central
Double-strand break repair via break-induced replication Source: GO_Central
Mitotic DNA replication preinitiation complex assembly Source: GO_Central
Regulation of chromatin silencing at telomere Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Meier-Gorlin syndrome 7 (MGORS7): A form of Meier-Gorlin syndrome, a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. MGORS7 inheritance is autosomal recessive.

Li, G. S., Yang, L. J., Chen, G., Huang, S. N., Fang, Y. Y., Huang, W. J., ... & Lu, H. P. (2021). Laryngeal Squamous Cell Carcinoma: Clinical Significance and Potential Mechanism of Cell Division Cycle 45. Cancer Biotherapy & Radiopharmaceuticals.

Lu, H. P., Du, X. F., Li, J. D., Huang, S. N., He, R. Q., Wu, H. Y., ... & Chen, G. (2021). Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e928800-1.

Yang, C., Wu, Y., Ru, G., He, X., Pan, H. Y., Wang, S., & Tong, X. (2021). Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma. PeerJ, 9, e10824.

Zhang, R., Liu, Z., & Zhang, G. (2021). CDC45 modulates MCM7 expression and inhibits cell proliferation by suppressing the PI3K/AKT pathway in acute myeloid leukemia. American Journal of Translational Research, 13(9), 10218.

He, Z., Wang, X., Yang, Z., Jiang, Y., Li, L., Wang, X., ... & Cui, R. (2021). Expression and prognosis of CDC45 in cervical cancer based on the GEO database. PeerJ, 9, e12114.

Yang, S., Ren, X., Liang, Y., Yan, Y., Zhou, Y., Hu, J., ... & Liang, L. (2020). KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis. Oncogene, 39(2), 249-261.

Yang, C., Xie, S., Wu, Y., Ru, G., He, X., Pan, H., ... & Tong, X. (2020). Prognostic implications of CDC45 expression in hepatocellular carcinoma.

Perl, A. L., O’Connor, C. M., Fa, P., Pozo, F. M., Zhang, J., Zhang, Y., & Narla, G. (2019). Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). Journal of Biological Chemistry, 294(45), 17043-17059.

Huang, J., Li, Y., Lu, Z., Che, Y., Sun, S., Mao, S., ... & He, J. (2019). Analysis of functional hub genes identifies CDC45 as an oncogene in non-small cell lung cancer-a short report. Cellular Oncology, 42(4), 571-578.

Sun, J., Shi, R., Zhao, S., Li, X., Lu, S., Bu, H., & Ma, X. (2017). Cell division cycle 45 promotes papillary thyroid cancer progression via regulating cell cycle. Tumor Biology, 39(5), 1010428317705342.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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