CDC45

CDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include Meier-Gorlin Syndrome 7 and Meier-Gorlin Syndrome 1. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include chromatin binding and DNA replication origin binding.
Full Name
Cell Division Cycle 45
Function
Required for initiation of chromosomal DNA replication.
Biological Process
DNA replication Source: Reactome
DNA replication checkpoint Source: ProtInc
DNA replication initiation Source: GO_Central
Double-strand break repair via break-induced replication Source: GO_Central
Mitotic DNA replication preinitiation complex assembly Source: GO_Central
Regulation of chromatin silencing at telomere Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Meier-Gorlin syndrome 7 (MGORS7): A form of Meier-Gorlin syndrome, a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. MGORS7 inheritance is autosomal recessive.
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Anti-CDC45 antibodies

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Mouse Anti-CDC45 Recombinant Antibody (C6005) (CBMAB-C6005-LY)

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Target: CDC45
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: C6005
Application*: E, WB, IF
Datasheet SDS

Rabbit Anti-CDC45 Recombinant Antibody (CBNH-036) (CBMAB-R4361-CN)

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Target: CDC45
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBNH-036
Application*: WB, IF, F, IH
Datasheet SDS

Rabbit Anti-CDC45 Recombinant Antibody (
4B4) (V2LY-0725-LY651)

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Target: CDC45
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4B4
Application*: E
Datasheet SDS

Mouse Anti-CDC45 Recombinant Antibody (4C2) (CBMAB-A1410-LY)

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Target: CDC45L
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C2
Application*: WB, E
Datasheet SDS

Mouse Anti-CDC45 Recombinant Antibody (CBFYC-1523) (CBMAB-C1582-FY)

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Target: CDC45
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1523
Application*: WB, IF, IP, E
Datasheet SDS

Mouse Anti-CDC45 Recombinant Antibody (C0618) (CBMAB-C0618-LY)

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Target: CDC45
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: C0618
Application*: WB, IF, IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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