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Mouse Anti-CDC7 Recombinant Antibody (3F113) (CBMAB-C0333-YY)

This product is mouse antibody that recognizes CDC7. The antibody 3F113 can be used for immunoassay techniques such as: IHC, IP, WB
See all CDC7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F113
Antibody Isotype
IgG1
Application
IHC, IP, WB

Basic Information

Immunogen
GST fusion protein full length CDC7. Cellular Localization: Nuclear
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
0.1 mg/mL
Preservative
PBS, pH 7.4, 0.2% BSA, 40% glycerol
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle 7
Entrez Gene ID
8317
UniProt ID
O00311
Alternative Names
CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4;
Function
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3.
Biological Process
Cell cycle phase transition Source: BHF-UCL
Cell division Source: UniProtKB-KW
DNA replication Source: Reactome
DNA replication initiation Source: Reactome
Double-strand break repair via break-induced replication Source: GO_Central
G1/S transition of mitotic cell cycle Source: ProtInc
Negative regulation of G0 to G1 transition Source: Reactome
Peptidyl-serine phosphorylation Source: GO_Central
Positive regulation of cell population proliferation Source: HGNC-UCL
Positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
Positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
Cellular Location
Nucleus

Vaca, G., Martinez‐Gonzalez, L., Fernandez, A., Rojas‐Prats, E., Porras, G., Cuevas, E. P., ... & Martin‐Requero, Á. (2021). Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Journal of Neurochemistry, 156(3), 379-390.

Rojas-Prats, E., Martinez-Gonzalez, L., Gonzalo-Consuegra, C., Liachko, N. F., Perez, C., Ramírez, D., ... & Martinez, A. (2021). Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis. European Journal of Medicinal Chemistry, 210, 112968.

Iwai, K., Nambu, T., Kashima, Y., Yu, J., Eng, K., Miyamoto, K., ... & Ohashi, A. (2021). A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery. Science Advances, 7(21), eabf0197.

Ma, Q., Zhang, J., Zhang, M., Lan, H., Yang, Q., Li, C., & Zeng, L. (2020). MicroRNA-29b targeting of cell division cycle 7-related protein kinase (CDC7) regulated vascular smooth muscle cell (VSMC) proliferation and migration. Annals of Translational Medicine, 8(22).

Jaafari-Ashkavandi, Z., Ashraf, M. J., & Abbaspoorfard, A. A. (2019). Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation☆. Brazilian journal of otorhinolaryngology, 85, 144-149.

Gad, S. A., Ali, H. E., Gaballa, R., Abdelsalam, R. M., Zerfaoui, M., Ali, H. I., ... & Abd Elmageed, Z. Y. (2019). Targeting CDC7 sensitizes resistance melanoma cells to BRAF V600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway. Scientific reports, 9(1), 1-12.

Shimizu, T., Doi, T., Kondo, S., Takahashi, H., Yamamoto, N., Sheldon-Waniga, E., ... & Kuboki, Y. (2018). First-in-human phase 1 study of TAK-931, an oral cell division cycle 7 (CDC7) inhibitor, in patients (pts) with advanced solid tumors.

Jin, S., Ma, H., Yang, W., Ju, H., Wang, L., & Zhang, Z. (2018). Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1. Journal of Molecular Medicine, 96(6), 513-525.

Li, X., Qian, X., Jiang, H., Xia, Y., Zheng, Y., Li, J., ... & Lu, Z. (2018). Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Molecular cell, 72(4), 650-660.

Locuson, C., Patel, M., Ohashi, A., Iwai, K., Nambu, T., Takeuchi, T., ... & Xia, C. (2017). Translational pharmacokinetic-pharmacodynamic xenograft model for TAK-931, a small molecule cell division cycle 7 (CDC7) kinase inhibitor.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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