Mouse Anti-CDH11 Recombinant Antibody (CBFYC-1542) (CBMAB-C1601-FY)

Name: Mouse Anti-CDH11 Recombinant Antibody (CBFYC-1542)
SKU: CBMAB-C1601-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1542

Application

ELISA

Immunogen

CDH11 (54 a.a. ~ 612 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cadherin 11

Introduction

CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include Aneurysmal Bone Cysts and Deafness, Autosomal Recessive 89. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH8.

Entrez Gene ID

1009

UniProt ID

P55287

Alternative Names

Cadherin 11; Cadherin 11, Type 2, OB-Cadherin (Osteoblast); OB-Cadherin; OSF-4; Osteoblast Cadherin; Cadherin-11; CAD11; CDHOB; OB

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.

Topology

Extracellular: 54-617
Helical: 618-640
Cytoplasmic: 641-796

Chen, X., Xiang, H., Yu, S., Lu, Y., & Wu, T. (2021). Research progress in the role and mechanism of Cadherin-11 in different diseases. Journal of Cancer, 12(4), 1190.

Cao, W., Song, S., Fang, G., Li, Y., Wang, Y., & Wang, Q. S. (2021). Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation. Journal of Inflammation Research, 14, 2897.

Johnson, C. L., Riley, L., Bersi, M., Linton, M. F., & Merryman, W. D. (2021). Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H756-H769.

Manohar, S., Camacho-Magallanes, A., Echeverria Jr, C., & Rogers, C. D. (2020). Cadherin-11 is required for neural crest specification and survival. Frontiers in physiology, 11.

Wang, T., Zhou, Q., & Shang, Y. (2020). MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice. International immunopharmacology, 83, 106440.

Satriyo, P. B., Bamodu, O. A., Chen, J. H., Aryandono, T., Haryana, S. M., Yeh, C. T., & Chao, T. Y. (2019). Cadherin 11 inhibition downregulates β-catenin, deactivates the canonical WNT signalling pathway and suppresses the cancer stem cell-like phenotype of triple negative breast cancer. Journal of clinical medicine, 8(2), 148.

Yuan, S., Li, L., Xiang, S., Jia, H., & Luo, T. (2019). Cadherin-11 is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor. Cancer management and research, 11, 2517.

Pedroza, M., To, S., Smith, J., & Agarwal, S. K. (2019). Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride. PloS one, 14(7), e0218971.

Bowler, M. A., Bersi, M. R., Ryzhova, L. M., Jerrell, R. J., Parekh, A., & Merryman, W. D. (2018). Cadherin-11 as a regulator of valve myofibroblast mechanobiology. American Journal of Physiology-Heart and Circulatory Physiology, 315(6), H1614-H1626.

Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., ... & Wang, T. (2018). The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncology letters, 15(2), 1417-1422.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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