CDH11
CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include Aneurysmal Bone Cysts and Deafness, Autosomal Recessive 89. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH8.
Full Name
Cadherin 11
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Biological Process
Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
Topology
Extracellular: 54-617
Helical: 618-640
Cytoplasmic: 641-796
Helical: 618-640
Cytoplasmic: 641-796
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Anti-CDH11 antibodies
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CompareTarget: CDH11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cat
Clone: EG581
Application*: WB
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C1722
Application*: E, WB
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1720
Application*: E, WB
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYC-1546
Application*: WB, E, IF, IP
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1544
Application*: E, WB
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1543
Application*: WB, E, IF
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1542
Application*: E
Target: CDH11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 4D10
Application*: E
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXO-0467
Application*: WB, IF, IP, E
Target: CDH11
Sensitivity: 0.025 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Cdh11
Sensitivity: 0.052 ng/mL
Detection Range: 0.1-38 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CDH11
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 54-617
Tag: His Tag
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3312
Application*: IH, IC, F
Target: CDH11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3619
Application*: WB, IH, IC, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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