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CDH11

CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include Aneurysmal Bone Cysts and Deafness, Autosomal Recessive 89. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH8.

Full Name

Cadherin 11

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.

Topology

Extracellular: 54-617
Helical: 618-640
Cytoplasmic: 641-796

Anti-CDH11 antibodies

Mouse Anti-CDH11 Recombinant Antibody (CBXC-1276) (CBMAB-C1543-CQ)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1276

Application*: F

Mouse Anti-CDH11 Recombinant Antibody (CBXC-2441) (CBMAB-C0043-CQ)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXC-2441

Application*: WB, IH, IF, C

Mouse Anti-CDH11 Recombinant Antibody (CBYY-C1723) (CBMAB-C3161-YY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1723

Application*: E, WB, P, IF, F

Mouse Anti-CDH11 Recombinant Antibody (CBYY-C1722) (CBMAB-C3160-YY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-C1722

Application*: E

Mouse Anti-CDH11 Recombinant Antibody (CBYY-C1720) (CBMAB-C3158-YY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBYY-C1720

Application*: IC, IH, WB

Mouse Anti-CDH11 Recombinant Antibody (667039) (CBMAB-C1512-YY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 667039

Application*: F

Mouse Anti-CDH11 Recombinant Antibody (CBFYC-1546) (CBMAB-C1605-FY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBFYC-1546

Application*: IC, IF, C, WB

Mouse Anti-CDH11 (AA 54-612) Recombinant Antibody (CBFYC-1544) (CBMAB-C1603-FY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-1544

Application*: E, F, FN, IP, WB

Mouse Anti-CDH11 (AA 23-617) Recombinant Antibody (CBFYC-1543) (CBMAB-C1602-FY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1543

Application*: WB, IH

Mouse Anti-CDH11 Recombinant Antibody (CBFYC-1542) (CBMAB-C1601-FY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-1542

Application*: F

Mouse Anti-CDH11 Recombinant Antibody (16G5) (CBMAB-O0223-CQ)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 16G5

Application*: WB, IF, IP

Mouse Anti-CDH11 Recombinant Antibody (CBXO-0467) (CBMAB-O0006-CQ)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXO-0467

Application*: WB, C

Rabbit Anti-CDH11 Recombinant Antibody (EG581) (CBMAB-EN702-LY)

SDS

Target: CDH11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG581

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Mouse Anti-CDH11 Recombinant Antibody (3C8) (CBMAB-A1429-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3C8

Application*: WB, E

Mouse Anti-CDH11 Recombinant Antibody (2D1) (CBMAB-A1425-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D1

Application*: WB, E

Mouse Anti-CDH11 Recombinant Antibody (5F82) (CBMAB-C2069-CN)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F82

Application*: IH

Mouse Anti-CDH11 Recombinant Antibody (3G41) (CBMAB-C2067-CN)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 3G41

Application*: E, IH, IP, WB

Mouse Anti-CDH11 Recombinant Antibody (5B2H5) (CBMAB-C7314-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5B2H5

Application*: E, C, P, IP, WB

Mouse Anti-CDH11 Recombinant Antibody (4E12G10) (CBMAB-C6850-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E12G10

Application*: E, WB, P, IF/C, F

Mouse Anti-CDH11 Recombinant Antibody (4D10) (CBMAB-C6768-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4D10

Application*: E

Mouse Anti-CDH11 Recombinant Antibody (4A11) (CBMAB-C6549-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 4A11

Application*: IC, C, WB

Mouse Anti-CDH11 Recombinant Antibody (3E2) (CBMAB-C5944-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3E2

Application*: E, WB

Mouse Anti-CDH11 Recombinant Antibody (3C11) (CBMAB-C5782-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3C11

Application*: E, WB

Mouse Anti-CDH11 Recombinant Antibody (2C79) (CBMAB-C4819-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2C79

Application*: E, WB

Mouse Anti-CDH11 Recombinant Antibody (2C12A6) (CBMAB-C4762-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C12A6

Application*: E, WB, P, IF/C, F

Mouse Anti-CDH11 Recombinant Antibody (283416) (CBMAB-C0788-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 283416

Application*: WB, IH

Mouse Anti-CDH11 Recombinant Antibody (16A) (CBMAB-C0399-LY)

SDS

Target: CDH11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 16A

Application*: WB, IH, IC/IF, C

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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