Human CDH11 ELISA Kit (V2LY-0626-LY3734)

Name: Human CDH11 ELISA Kit
SKU: V2LY-0626-LY3734
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.025 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

88.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Cadherin 11

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.

Topology

Extracellular: 54-617
Helical: 618-640
Cytoplasmic: 641-796

Chen, X., Xiang, H., Yu, S., Lu, Y., & Wu, T. (2021). Research progress in the role and mechanism of Cadherin-11 in different diseases. Journal of Cancer, 12(4), 1190.

Cao, W., Song, S., Fang, G., Li, Y., Wang, Y., & Wang, Q. S. (2021). Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation. Journal of Inflammation Research, 14, 2897.

Johnson, C. L., Riley, L., Bersi, M., Linton, M. F., & Merryman, W. D. (2021). Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H756-H769.

Manohar, S., Camacho-Magallanes, A., Echeverria Jr, C., & Rogers, C. D. (2020). Cadherin-11 is required for neural crest specification and survival. Frontiers in physiology, 11.

Wang, T., Zhou, Q., & Shang, Y. (2020). MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice. International immunopharmacology, 83, 106440.

Satriyo, P. B., Bamodu, O. A., Chen, J. H., Aryandono, T., Haryana, S. M., Yeh, C. T., & Chao, T. Y. (2019). Cadherin 11 inhibition downregulates β-catenin, deactivates the canonical WNT signalling pathway and suppresses the cancer stem cell-like phenotype of triple negative breast cancer. Journal of clinical medicine, 8(2), 148.

Yuan, S., Li, L., Xiang, S., Jia, H., & Luo, T. (2019). Cadherin-11 is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor. Cancer management and research, 11, 2517.

Pedroza, M., To, S., Smith, J., & Agarwal, S. K. (2019). Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride. PloS one, 14(7), e0218971.

Bowler, M. A., Bersi, M. R., Ryzhova, L. M., Jerrell, R. J., Parekh, A., & Merryman, W. D. (2018). Cadherin-11 as a regulator of valve myofibroblast mechanobiology. American Journal of Physiology-Heart and Circulatory Physiology, 315(6), H1614-H1626.

Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., ... & Wang, T. (2018). The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncology letters, 15(2), 1417-1422.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Cdh11 ELISA Kit (CAT#: V2LY-0626-LY1619)

Human Recombinant CDH11 protein, His Tag (CAT#: V2LY-0526-LY2486)

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Mouse Anti-CDH11 Recombinant Antibody (CBFYC-1546) (CAT#: CBMAB-C1605-FY)

Mouse Cdh11 ELISA Kit (CAT#: V2LY-0626-LY1619)

Human Recombinant CDH11 protein, His Tag (CAT#: V2LY-0526-LY2486)

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Mouse Anti-CDH11 Recombinant Antibody (CBT3619) (CAT#: V2LY-0625-LY506)

Isotype control

For research use only. Not intended for any clinical use.

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