Mouse Anti-CDH17 Recombinant Antibody (CBYJL-159) (CBMAB-L0237-YJ)

Name: Mouse Anti-CDH17 Recombinant Antibody (CBYJL-159)
SKU: CBMAB-L0237-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-159

Application

WB, ELISA, IF, IP, IHC-P

Immunogen

Amino acids 666-832 mapping at the C-terminus of LI-cadherin of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cadherin 17

Introduction

Diseases associated with CDH17 include Gastric Adenocarcinoma and Gastric Cancer. Among its related pathways are Gastric cancer and ERK Signaling. Gene Ontology (GO) annotations related to this gene include proton-dependent oligopeptide secondary active transmembrane transporter activity and calcium ion binding. An important paralog of this gene is CDH16.

Entrez Gene ID

1015

UniProt ID

Q12864

Alternative Names

Cadherin 17; Intestinal Peptide-Associated Transporter HPT-1; Cadherin 17; LI Cadherin (Liver-Intestine); Liver-Intestine Cadherin; Human Intestinal Peptide-Associated Transporter HPT-1; Human Peptide Transporter 1; HPT-1 Cadherin; Cadherin-16

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Biological Process

Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Germinal center B cell differentiation Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Marginal zone B cell differentiation Source: Ensembl
Oligopeptide transmembrane transport Source: UniProtKB
Oligopeptide transport Source: UniProtKB
Positive regulation of integrin activation by cell surface receptor linked signal transduction Source: UniProtKB
Spleen development Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 23-787
Helical: 788-808
Cytoplasmic: 809-832

Gray, M. E., & Sotomayor, M. (2021). Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. Acta Crystallographica Section F: Structural Biology Communications, 77(3).

Zheng, B., Shen, S., Wong, T. K., Gong, Z. J., Sun, W., Ni, X., ... & Suo, T. (2021). Clinical correlation of cadherin-17 (CA17 aka CDH17) marker with advanced tumor stages and poor prognosis of cholangiocarcinoma in a retrospective cohort of 180 patients.

Lum, Y. L., Luk, J. M., Staunton, D. E., Ng, D. K., & Fong, W. P. (2020). Cadherin-17 Targeted near-infrared photoimmunotherapy for treatment of gastrointestinal cancer. Molecular Pharmaceutics, 17(10), 3941-3951.

Atukorala, I., & Mathivanan, S. (2018). PO-066 Knockdown of cadherin 17 inactivates WNT signalling pathway and induces apoptosis in colorectal cancer cells. ESMO Open, 3, A47.

Chang, Y. Y., Yu, L. C. H., Yu, I. S., Jhuang, Y. L., Huang, W. J., Yang, C. Y., & Jeng, Y. M. (2018). Deletion of cadherin‐17 enhances intestinal permeability and susceptibility to intestinal tumour formation. The Journal of pathology, 246(3), 289-299.

Lee, C. W., Lin, S. E., Tsai, H. I., Su, P. J., Hsieh, C. H., Kuo, Y. C., ... & Yu, M. C. (2018). Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma. Oncology letters, 15(1), 559-567.

Tian, X., Han, Z., Zhu, Q., Tan, J., Liu, W., Wang, Y., ... & Huang, X. (2018). Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. Biomedicine & Pharmacotherapy, 108, 331-337.

Bian, T., Zhao, J., Feng, J., Zhang, Q., Qian, L., Liu, J., ... & Zhang, J. (2017). Combination of cadherin-17 and SATB homeobox 2 serves as potential optimal makers for the differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. Oncotarget, 8(38), 63442.

Shek, F. H., Luo, R., Lam, B. Y., Sung, W. K., Lam, T. W., Luk, J. M., ... & Lee, N. P. (2017). Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma. Cellular Oncology, 40(5), 443-456.

Smith, A. R., Rota, I. A., Maio, S., Massaad, M. J., Lund, T. C., Notarangelo, L. D., ... & Blazar, B. R. (2017). Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT. Blood advances, 1(23), 2083.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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