Mouse Anti-CDH26 Recombinant Antibody (6C10) (CBMAB-C8113-LY)

Name: Mouse Anti-CDH26 Recombinant Antibody (6C10)
SKU: CBMAB-C8113-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6C10

Application

ELISA, WB

Immunogen

CDH26 (1 a.a. ~ 165 a.a) full-length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cadherin 26

Introduction

CDH26 (Cadherin 26) is a Protein Coding gene. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

Entrez Gene ID

60437

UniProt ID

Q8IXH8

Alternative Names

Cadherin 26; Cadherin-Like Protein VR20; Cadherin-Like 26; Cadherin-Like Protein 26; VR20;

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4+ T cells activation (PubMed:28051089).

Biological Process

CD4-positive, alpha-beta T cell activation Source: UniProtKB
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 28-614
Helical: 615-635
Cytoplasmic: 636-832

PTM

N-glycosylated.

Wagner, R., Li, H., Ayoub, L., Kahnamoui, S., Patel, D., Stefanovici, C., ... & Keijzer, R. (2021). Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation. Pediatric Surgery International, 37(1), 49-57.

Feng, Y., Chen, S., Chang, C., Wu, W., Chen, D., Gao, J., ... & Zhen, G. (2020). CDH26 amplifies airway epithelial IL-4 receptor α signaling in asthma. medRxiv.

Lachowicz-Scroggins, M. E., Gordon, E. D., Wesolowska-Andersen, A., Jackson, N. D., MacLeod, H. J., Sharp, L. Z., ... & Fahy, J. V. (2018). Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell discovery, 4(1), 1-15.

Caldwell, J. M., Collins, M. H., Kemme, K. A., Sherrill, J. D., Wen, T., Rochman, M., ... & Rothenberg, M. E. (2017). Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal immunology, 10(5), 1190-1201.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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