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Mouse Anti-CDK3 Recombinant Antibody (3C12) (CBMAB-C5794-LY)

This product is antibody recognizes CDK3. The antibody 3C12 immunoassay techniques such as: ELISA, WB.
See all CDK3 antibodies
Published Data
Fig. 1 Western blot
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3C12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cyclin-dependent kinase 3
Introduction
CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Among its related pathways are Cell Cycle Control of Chromosomal Replication and GADD45 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.
Entrez Gene ID
1018
UniProt ID
Q00526
Alternative Names
Cyclin Dependent Kinase 3; EC 2.7.11.22; Cell Division Protein Kinase 3; EC 2.7.11; CDKN3;
Function
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
Biological Process
Cell division Source: UniProtKB-KW
Cell population proliferation Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
G0 to G1 transition Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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