Human Recombinant CDK3 & CCNE1, Active protein, GST Tag (V2LY-0526-LY3036)

Name: Human Recombinant CDK3 & CCNE1, Active protein, GST Tag
SKU: V2LY-0526-LY3036
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CDK3 & CCNE1, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 60 kDa.

Molecule Mass

60 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

cyclin-dependent kinase 3

Function

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Biological Process

Cell division Source: UniProtKB-KW
Cell population proliferation Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
G0 to G1 transition Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central

Cellular Location

Nucleus

Liu, Z. H., Yang, S. Z., Li, W. Y., Dong, S. Y., Zhou, S. Y., & Xu, S. (2021). CircRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. Aging (Albany NY), 13(8), 12179.

Bailey, K., & Meredith, H. (2019). Effect of Mine Runoff Metals on the Cyclin-Dependent Kinase 3 (CDK3) Gene of Tetrahymena thermophila.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CDK3 & CCNE2, Active protein, GST Tag (CAT#: V2LY-0526-LY3037)

Human Recombinant CDK3 protein, GST Tag (CAT#: V2LY-0526-LY3038)

Related Products

Human Recombinant CDK3 protein, GST Tag (CAT#: V2LY-0526-LY3038)

Human Recombinant CDK3 & CCNE2, Active protein, GST Tag (CAT#: V2LY-0526-LY3037)

Mouse Anti-CDK3 Recombinant Antibody (3C12) (CAT#: CBMAB-C5794-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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