Mouse Anti-CDS2 Recombinant Antibody (CBXC-0351) (CBMAB-C3775-CQ)

This product is a mouse antibody that recognizes CDS2. The antibody CBXC-0351 can be used for immunoassay techniques such as: ELISA, WB.
See all CDS2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-0351

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

Introduction

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.

Entrez Gene ID

8760

UniProt ID

O95674

Alternative Names

CDP-Diacylglycerol Synthase 2; EC 2.7.7.41; CTP:Phosphatidate Cytidylyltransferase 2; Phosphatidate Cytidylyltransferase 2; CDP-Diglyceride Pyrophosphorylase 2; CDP-Diglyceride Synthase 2;

Function

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833).
Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833).
Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309).

Biological Process

CDP-diacylglycerol biosynthetic process Source: UniProtKB
Lipid droplet formation Source: UniProtKB
Phosphatidylglycerol biosynthetic process Source: Reactome

Cellular Location

Endoplasmic reticulum membrane

References

Xu, J., Chen, S., Wang, W., Lam, S. M., Xu, Y., Zhang, S., ... & Huang, X. (2021). Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Science Bulletin.

Mak, H. Y., Ouyang, Q., Tumanov, S., Xu, J., Rong, P., Dong, F., ... & Yang, H. (2021). AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nature communications, 12(1), 1-14.

Blunsom, N. J. (2020). Different CDP-diacylglycerol Synthase (CDS) enzymes participate in the synthesis of cardiolipin in mitochondria and phosphatidylinositol at the endoplasmic reticulum (Doctoral dissertation, UCL (University College London)).

Jennings, W., & Epand, R. M. (2020). CDP-diacylglycerol, a critical intermediate in lipid metabolism. Chemistry and physics of lipids, 230, 104914.

Xu, Y., Mak, H. Y., Lukmantara, I., Li, Y. E., Hoehn, K. L., Huang, X., ... & Yang, H. (2019). CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. Journal of Biological Chemistry, 294(45), 16740-16755.

Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., ... & Pan, W. (2019). Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell research, 29(11), 895-910.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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