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Mouse Anti-CEBPD Recombinant Antibody (CBXC-1705) (CBMAB-C3007-CQ)

This product is a mouse antibody that recognizes CEBPD. The antibody CBXC-1705 can be used for immunoassay techniques such as: WB.
See all CEBPD antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBXC-1705
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant corresponding to full length mouse C/EBP beta protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CCAAT/Enhancer Binding Protein Delta
Introduction
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11.
Entrez Gene ID
UniProt ID
Alternative Names
CCAAT/Enhancer Binding Protein Delta; CCAAT/Enhancer Binding Protein (C/EBP), Delta; Nuclear Factor NF-IL6-Beta; C/EBP Delta; NF-IL6-Beta; CCAAT/Enhancer-Binding Protein Delta; C/EBP-Delta; CELF; CRP3;
Function
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300).
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300).
Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
Biological Process
Cytokine-mediated signaling pathway Source: Reactome
Regulation of cell differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Viral life cycle Source: Reactome
Cellular Location
Nucleus

Wang, S. M., Lin, W. C., Lin, H. Y., Chen, Y. L., Ko, C. Y., & Wang, J. M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1-11.

Liu, L., Zhong, J., Chen, B., Wang, W., Xi, H., & Su, X. (2021). CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection. Journal of Leukocyte Biology.

Duitman, J., Hartl, L., Roelofs, J. J., Bijlsma, M. F., & Spek, C. A. (2021). Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation. Biomolecules, 11(8), 1079.

Spek, C. A., Aberson, H. L., Butler, J. M., de Vos, A. F., & Duitman, J. (2021). CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. Cells, 10(9), 2233.

Wang, S. M., Lin, H. Y., Chen, Y. L., Hsu, T. I., Chuang, J. Y., Kao, T. J., & Ko, C. Y. (2019). CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation. Journal of neuroinflammation, 16(1), 1-12.

Liu, P., Cao, W., Ma, B., Li, M., Chen, K., Sideras, K., ... & Peppelenbosch, M. P. (2019). Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma. Carcinogenesis, 40(1), 155-163.

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y., & Wang, J. M. (2018). Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation. Redox biology, 16, 104-112.

Tsai, H. H., Lai, H. Y., Chen, Y. C., Li, C. F., Huang, H. S., Liu, H. S., ... & Wang, J. M. (2017). Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway. Oncotarget, 8(8), 13832.

Lai, H. Y., Hsu, L. W., Tsai, H. H., Lo, Y. C., Yang, S. H., Liu, P. Y., & Wang, J. M. (2017). CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions. Cardiovascular research, 113(11), 1376-1388.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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