Rabbit Anti-CELA3B Recombinant Antibody (CBXC-0362) (CBMAB-C3193-CQ)

Name: Rabbit Anti-CELA3B Recombinant Antibody (CBXC-0362)
SKU: CBMAB-C3193-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXC-0362

Application

IHC

Immunogen

Recombinant human Elastase protein fragment (aa 82-238).

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	1-2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Chymotrypsin Like Elastase Family Member 3B

Introduction

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Entrez Gene ID

23436

UniProt ID

P08861

Alternative Names

Chymotrypsin Like Elastase Family Member 3B; Cholesterol-Binding Pancreatic Protease; Pancreatic Endopeptidase E; Elastase 3B, Pancreatic; Elastase IIIB; Proteinase E; Elastase-3B; Protease E; ELA3B;

Function

Efficient protease with alanine specificity but only little elastolytic activity.

Biological Process

Proteolysis Source: GO_Central

Cellular Location

Extracellular space

Masson, E., Rebours, V., Buscail, L., Frete, F., Pagenault, M., Lachaux, A., ... & Chen, J. M. (2021). The reversion variant (p. Arg90Leu) at the evolutionarily adaptive p. Arg90 site in CELA3B predisposes to chronic pancreatitis. Human Mutation, 42(4), 385-391.

Moore, P. C., Cortez, J. T., Chamberlain, C. E., Alba, D., Berger, A. C., Quandt, Z., ... & Oakes, S. A. (2019). Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. The Journal of clinical investigation, 129(11), 4676-4681.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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