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CELA3B

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

Full Name

Chymotrypsin Like Elastase Family Member 3B

Function

Efficient protease with alanine specificity but only little elastolytic activity.

Biological Process

Proteolysis Source: GO_Central

Cellular Location

Extracellular space

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Anti-CELA3B antibodies

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Mouse Anti-CELA3B Recombinant Antibody (CBWJC-2467) (CBMAB-C3536WJ)

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Target: CELA3B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-2467

Application*: E, WB

Mouse Anti-CELA3B Recombinant Antibody (2H6) (CBMAB-C13091-LY)

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Target: CELA3B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2H6

Application*: E

Mouse Anti-CELA3B Recombinant Antibody (C4185) (CBMAB-C4185-CQ)

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Target: CELA3B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: C4185

Application*: E, IH

Rabbit Anti-CELA3B Recombinant Antibody (C4184) (CBMAB-C4184-CQ)

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Target: CELA3B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: C4184

Application*: IH

Rabbit Anti-CELA3B Recombinant Antibody (CBXC-0362) (CBMAB-C3193-CQ)

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Target: CELA3B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXC-0362

Application*: IH

Mouse Anti-CELA3B Recombinant Antibody (CBFYE-0337) (CBMAB-E0629-FY)

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Target: CELA3B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0337

Application*: WB, E, IH

Human CELA3B ELISA Kit (V2LY-0626-LY5696)

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Target: CELA3B

Sensitivity: 0.053 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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