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Mouse Anti-CETN1 Recombinant Antibody (CBFYC-1737) (CBMAB-C1799-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1737
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
C-terminus region of human Centrin 1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Centrin 1
Introduction
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.
Entrez Gene ID
1068
UniProt ID
Q12798
Alternative Names
Centrin 1; Centrin, EF-Hand Protein, 1; CETN; CEN1; Testicular Tissue Protein Li 37; Calcium Binding Protein
Function
Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926).
Plays a role in sperm cilia formation (By similarity).
Biological Process
Aggrephagy Source: Reactome
Cell division Source: UniProtKB-KW
Centriole replication Source: GO_Central
Mitotic cell cycle Source: GO_Central
Nucleotide-excision repair Source: GO_Central
Cellular Location
Centrosome; Cilium. Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity).
More Infomation

Phanindranath, R., Sudhakar, D. V., Thangaraj, K., & Sharma, Y. (2021). Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1. Biochemical and Biophysical Research Communications, 570, 67-73.

Parizi, P. K., Seresht, L. M., Esmaeili, S. A., Jazi, A. D., Sarli, A., Khosravian, F., & Salehi, M. (2021). Evaluation of the association between centrosome amplification in tumor tissue of breast cancer patients and changes in the expression of CETN1 and CNTROB genes. Gene Reports, 101481.

Moretti, E., Noto, D., Guazzo, R., Menchiari, A., Belmonte, G., & Collodel, G. (2021). Centriolar defects, centrin 1 alterations, and FISH studies in human spermatozoa of a male partner of a couple that produces aneuploid embryos in natural and artificial fertilization. Journal of Assisted Reproduction and Genetics, 1-9.

Jiao, R., Allen, K. J., Malo, M. E., Helal, M., Jiang, Z., Smart, K., ... & Dadachova, E. (2019). Evaluation of novel highly specific antibodies to cancer testis antigen Centrin‐1 for radioimmunoimaging and radioimmunotherapy of pancreatic cancer. Cancer medicine, 8(11), 5289-5300.

Jiao, R., Allen, K., Malo, M., Jiang, Z., Smart, K., Buhl, S., ... & Dadachova, E. (2019). Evaluation of Novel Antibodies to Centrin-1 for Radioimmunotherapy of Pancreatic Cancer. Journal of Medical Imaging and Radiation Sciences, 50(1), S11.

Moretti, E., Pascarelli, N. A., Belmonte, G., Renieri, T., & Collodel, G. (2017). Sperm with fibrous sheath dysplasia and anomalies in head–neck junction: focus on centriole and centrin 1. Andrologia, 49(7), e12701.

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For research use only. Not intended for any clinical use.

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