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Mouse Anti-CFAP298 Recombinant Antibody (CBXC-2139) (CBMAB-C3439-CQ)

This product is a mouse antibody that recognizes C21orf59. The antibody CBXC-2139 can be used for immunoassay techniques such as: WB, IF, FC.
See all CFAP298 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2139
Antibody Isotype
IgG1
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human C21orf59 (NP_067077)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cilia And Flagella Associated Protein 298
Introduction
This gene a protein plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia.
Entrez Gene ID
56683
UniProt ID
P57076
Alternative Names
C21orf48; CILD26; FBB18; Kur
Function
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744).
Seems to be important for initiation rather than maintenance of cilium motility (By similarity).
Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity).
May suppress canonical Wnt signaling activity (By similarity).
Biological Process
Cilium assembly Source: UniProtKB
Regulation of cilium movement Source: UniProtKB
Cellular Location
Cytoplasm; Cilium basal body.Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
Involvement in disease
Ciliary dyskinesia, primary, 26 (CILD26): The disease is caused by variants affecting the gene represented in this entry. Cilia in nasal epithelia show the absence of both outer and inner dynein-arm components and complete paralysis. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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