Mouse Anti-CFC1 Recombinant Antibody (8D12) (CBMAB-C9123-LY)

Name: Mouse Anti-CFC1 Recombinant Antibody (8D12)
SKU: CBMAB-C9123-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8D12

Application

Immunogen

Recombinant human Cryptic Tyr26-Gly169.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

cripto, FRL-1, cryptic family 1

Introduction

This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Entrez Gene ID

55997

UniProt ID

P0CG37

Alternative Names

Cripto, FRL-1, Cryptic Family 1; Heterotaxy 2 (Autosomal Dominant); Cryptic Family Protein 1; Cryptic Protein; CRYPTIC; CFC1B; DTGA2; HTX2;

Function

NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.

Biological Process

Anatomical structure development Source: GO_Central
Anterior/posterior pattern specification Source: GO_Central
Blood vessel development Source: GO_Central
Determination of left/right symmetry Source: GO_Central
Gastrulation Source: UniProtKB-KW
Heart development Source: GO_Central
Nodal signaling pathway Source: UniProtKB

Cellular Location

Cell membrane; Secreted. Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.

Involvement in disease

Heterotaxy, visceral, 2, autosomal (HTX2): A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations.

PTM

N-glycosylated.

Chikaraishi, K., Takenobu, H., Sugino, R. P., Mukae, K., Akter, J., Haruta, M., ... & Kamijo, T. (2017). CFC1 is a cancer stemness-regulating factor in neuroblastoma. Oncotarget, 8(28), 45046.

Tsubota, S., & Kadomatsu, K. (2017). Neuroblastoma stem cells and CFC1. Oncotarget, 8(28), 45032.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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