Sign in or Register   Sign in or Register
  |  

CFC1

This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in this gene can cause autosomal visceral heterotaxy. This protein is involved in left-right asymmetric morphogenesis during organ development. [provided by RefSeq]
Full Name
cripto, FRL-1, cryptic family 1
Function
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
Biological Process
Anatomical structure development Source: GO_Central
Anterior/posterior pattern specification Source: GO_Central
Blood vessel development Source: GO_Central
Determination of left/right symmetry Source: GO_Central
Gastrulation Source: UniProtKB-KW
Heart development Source: GO_Central
Nodal signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Secreted. Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
Involvement in disease
Heterotaxy, visceral, 2, autosomal (HTX2): A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations.
PTM
N-glycosylated.

Anti-CFC1 antibodies

Loading...
Target: CFC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G4
Application*: E, IP, WB
Target: CFC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-1749
Application*: WB
Target: CFC1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-0449
Application*: F, IC, IF, WB
Target: CFC1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 221428
Application*: WB, F, IC
Target: CFC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 221423
Application*: WB
Target: CFC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0205-8D12
Application*: WB
Target: CFC1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0198-1M10
Application*: WB
Target: CFC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1901
Application*: WB
Target: CFC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D12
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare