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Mouse Anti-CFD Recombinant Antibody (H13/11) (CBMAB-A4300-YC)

Provided herein is a Mouse monoclonal antibody against Human Complement Factor D. The antibody can be used for immunoassay techniques, such as WB, IP.
See all CFD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H13/11
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Complement Factor D
Introduction
CFD is a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell sign
Entrez Gene ID
1675
UniProt ID
P00746
Alternative Names
Complement Factor D; Properdin Factor D; Adipsin; D Component Of Complement (Adipsin); C3 Convertase Activator; EC 3.4.21.46; PFD;
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Biological Process
Complement activation Source: ProtInc
Complement activation, alternative pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Notch signaling pathway Source: InterPro
Platelet degranulation Source: Reactome
Proteolysis Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Complement factor D deficiency (CFDD): An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Duan, C., Ma, Z., Wu, S., Ding, X., Tu, X., & Ye, J. (2021). Functional characterization of complement factor D on the defense against Gyrodactylus kobayashii (Monogenea) infection in goldfish (Carassius auratus). Aquaculture, 545, 737214.

Corvillo, F., González-Sánchez, L., López-Lera, A., Arjona, E., Ceccarini, G., Santini, F., ... & López-Trascasa, M. (2021). Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer–Simons syndrome). International Journal of Molecular Sciences, 22(12), 6608.

Langereis, J. D., van der Molen, R. G., de Kat Angelino, C., Henriet, S. S., de Jonge, M. I., Joosten, I., ... & van der Flier, M. (2021). Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing. Clinical & Translational Immunology, 10(4), e1256.

Wiles, J. A., Galvan, M. D., Podos, S. D., Geffner, M., & Huang, M. (2020). Discovery and development of the oral complement factor D inhibitor danicopan (ACH-4471). Current medicinal chemistry, 27(25), 4165-4180.

Qi, H., Wei, J., Gao, Y., Yang, Y., Li, Y., Zhu, H., ... & Yang, R. (2020). Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut. Communications biology, 3(1), 1-15.

Cho, H. Y., Park, H. S., Ko, E. J., Ryu, C. S., Kim, J. O., Kim, Y. R., ... & Kim, N. K. (2020). Association of complement factor D and H polymorphisms with recurrent pregnancy loss. International journal of molecular sciences, 21(1), 17.

Ezure, T., Sugahara, M., & Amano, S. (2019). Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D. BioFactors, 45(4), 556-562.

Yaspan, B. L., Williams, D. F., Holz, F. G., Regillo, C. D., Li, Z., Dressen, A., ... & MAHALO Study Investigators. (2017). Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration. Science translational medicine, 9(395).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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