CFD

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Full Name
Complement Factor D
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Biological Process
Complement activation Source: ProtInc
Complement activation, alternative pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Notch signaling pathway Source: InterPro
Platelet degranulation Source: Reactome
Proteolysis Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Complement factor D deficiency (CFDD): An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
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Anti-CFD antibodies

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Rat Anti-CFD Recombinant Antibody (C2405) (CBMAB-C2405-LY)

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Target: CFD
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: C2405
Application*: IP, WB
Datasheet SDS

Human Anti-CFD Recombinant Antibody (CBFYA-0195) (CBMAB-X0276-FY)

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Target: CFD
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0195
Application*: E, F
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBFYA-0194) (CBMAB-X0275-FY)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYA-0194
Application*: WB
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (D10/4) (CBMAB-C2622WJ)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D10/4
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBXC-1047) (CBMAB-C1311-CQ)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1047
Application*: E
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBFYC-1753) (CBMAB-C1815-FY)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1753
Application*: E
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBFYC-1752) (CBMAB-C1814-FY)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1752
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBFYC-1751) (CBMAB-C1813-FY)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1751
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (5F20) (CBMAB-C7568-LY)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5F20
Application*: E, WB
Datasheet SDS

Rabbit Anti-CFD Recombinant Antibody (CBYC-A936) (CBMAB-A4301-YC)

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Target: CFD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-A936
Application*: E, WB
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (H13/11) (CBMAB-A4300-YC)

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Target: CFD
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: H13/11
Application*: WB, IP
Datasheet SDS

Mouse Anti-CFD Recombinant Antibody (CBXF-1902) (CBMAB-F2021-CQ)

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Target: CFD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-1902
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CFD Recombinant Antibody (CBXF-1124) (CBMAB-F0753-CQ)

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Target: CFD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1124
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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