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CFD

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

Full Name

Complement Factor D

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Biological Process

Complement activation Source: ProtInc
Complement activation, alternative pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Notch signaling pathway Source: InterPro
Platelet degranulation Source: Reactome
Proteolysis Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Complement factor D deficiency (CFDD): An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Anti-CFD antibodies

Mouse Anti-CFD Recombinant Antibody (CBFYA-0195) (CBMAB-X0276-FY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0195

Application*: IA

Mouse Anti-CFD Recombinant Antibody (CBFYA-0194) (CBMAB-X0275-FY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYA-0194

Application*: IA

Rat Anti-CFD Recombinant Antibody (577620) (CBMAB-C7227-LY)

SDS

Target: CFD

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 577620

Application*: IP, WB

Rat Anti-CFD Recombinant Antibody (10K85) (CBMAB-C2405-LY)

SDS

Target: CFD

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 10K85

Application*: E, IP, WB

Recombinant Mouse Anti-CFD Antibody (CBHb294) (CBMAB-Hb384-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb294

Application*: Immuno assays

Recombinant Mouse Anti-CFD Antibody (CBHb293) (CBMAB-Hb383-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBHb293

Application*: Immuno assays

Mouse Anti-CFD Recombinant Antibody (MM0196-4M47) (CBMAB-C10920-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0196-4M47

Application*: WB

Mouse Anti-CFD Recombinant Antibody (6F82) (CBMAB-C0325-CN)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6F82

Application*: E, WB

Mouse Anti-CFD Recombinant Antibody (D10/4) (CBMAB-C2622WJ)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: D10/4

Application*: E, WB

Mouse Anti-CFD Recombinant Antibody (CBXC-1047) (CBMAB-C1311-CQ)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1047

Application*: EC

Rat Anti-CFD (AA 26-259) Recombinant Antibody (CBFYC-1754) (CBMAB-C1816-FY)

SDS

Target: CFD

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYC-1754

Application*: E, IP, WB

Mouse Anti-CFD Recombinant Antibody (CBFYC-1753) (CBMAB-C1815-FY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1753

Application*: E

Mouse Anti-CFD Recombinant Antibody (CBFYC-1752) (CBMAB-C1814-FY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1752

Application*: WB

Mouse Anti-CFD Recombinant Antibody (CBFYC-1751) (CBMAB-C1813-FY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBFYC-1751

Application*: WB

Mouse Anti-CFD Recombinant Antibody (5F20) (CBMAB-C7568-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 5F20

Application*: E, WB

Mouse Anti-CFD Recombinant Antibody (255706) (CBMAB-C4482-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 255706

Application*: WB

Mouse Anti-CFD Recombinant Antibody (14L276) (CBMAB-C3148-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L276

Application*: WB

Mouse Anti-CFD Recombinant Antibody (255719) (CBMAB-C0741-LY)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 255719

Application*: E, WB

Rabbit Anti-CFD Recombinant Antibody (CBYC-A936) (CBMAB-A4301-YC)

SDS

Target: CFD

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYC-A936

Application*: E

Mouse Anti-CFD Recombinant Antibody (H13/11) (CBMAB-A4300-YC)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: H13/11

Application*: WB, IP

Mouse Anti-CFD Recombinant Antibody (13) (CBMAB-A4298-YC)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13

Application*: E

Mouse Anti-CFD Recombinant Antibody (I8/1) (CBMAB-F2643-CQ)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: I8/1

Application*: E, WB

Mouse Anti-CFD Recombinant Antibody (CBXF-1902) (CBMAB-F2021-CQ)

SDS

Target: CFD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-1902

Application*: E, WB

Rabbit Anti-CFD Recombinant Antibody (CBXF-1124) (CBMAB-F0753-CQ)

SDS

Target: CFD

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1124

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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