Human Recombinant CFD protein, His Tag (V2LY-0526-LY3985)

Name: Human Recombinant CFD protein, His Tag
SKU: V2LY-0526-LY3985
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CFD protein, His Tag consist of Amino Acid: 26-253 and predicts a molecular mass of 25.8 kDa.

Molecule Mass

25.8 kDa

Sequence

Amino Acid: 26-253

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

HEPES, KCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Complement Factor D

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Biological Process

Complement activation Source: ProtInc
Complement activation, alternative pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Notch signaling pathway Source: InterPro
Platelet degranulation Source: Reactome
Proteolysis Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Complement factor D deficiency (CFDD): An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Duan, C., Ma, Z., Wu, S., Ding, X., Tu, X., & Ye, J. (2021). Functional characterization of complement factor D on the defense against Gyrodactylus kobayashii (Monogenea) infection in goldfish (Carassius auratus). Aquaculture, 545, 737214.

Corvillo, F., González-Sánchez, L., López-Lera, A., Arjona, E., Ceccarini, G., Santini, F., ... & López-Trascasa, M. (2021). Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer–Simons syndrome). International Journal of Molecular Sciences, 22(12), 6608.

Langereis, J. D., van der Molen, R. G., de Kat Angelino, C., Henriet, S. S., de Jonge, M. I., Joosten, I., ... & van der Flier, M. (2021). Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing. Clinical & Translational Immunology, 10(4), e1256.

Wiles, J. A., Galvan, M. D., Podos, S. D., Geffner, M., & Huang, M. (2020). Discovery and development of the oral complement factor D inhibitor danicopan (ACH-4471). Current medicinal chemistry, 27(25), 4165-4180.

Qi, H., Wei, J., Gao, Y., Yang, Y., Li, Y., Zhu, H., ... & Yang, R. (2020). Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut. Communications biology, 3(1), 1-15.

Cho, H. Y., Park, H. S., Ko, E. J., Ryu, C. S., Kim, J. O., Kim, Y. R., ... & Kim, N. K. (2020). Association of complement factor D and H polymorphisms with recurrent pregnancy loss. International journal of molecular sciences, 21(1), 17.

Ezure, T., Sugahara, M., & Amano, S. (2019). Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D. BioFactors, 45(4), 556-562.

Yaspan, B. L., Williams, D. F., Holz, F. G., Regillo, C. D., Li, Z., Dressen, A., ... & MAHALO Study Investigators. (2017). Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration. Science translational medicine, 9(395).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Cfd ELISA Kit (CAT#: V2LY-0626-LY1396)

Mouse Cfd ELISA Kit (CAT#: V2LY-0626-LY2218)

Human CFD ELISA Kit (CAT#: V2LY-0626-LY711)

Human Recombinant CFD protein, His Tag-1 (CAT#: V2LY-0526-LY3986)

Mouse Recombinant CFD protein, His Tag (CAT#: V2LY-0526-LY8287)

Related Products

Rat Cfd ELISA Kit (CAT#: V2LY-0626-LY1396)

Mouse Anti-CFD Recombinant Antibody (CBFYC-1751) (CAT#: CBMAB-C1813-FY)

Mouse Anti-CFD Recombinant Antibody (5F20) (CAT#: CBMAB-C7568-LY)

Mouse Anti-CFD Recombinant Antibody (H13/11) (CAT#: CBMAB-A4300-YC)

Mouse Anti-CFD Recombinant Antibody (CBXF-1902) (CAT#: CBMAB-F2021-CQ)

Mouse Cfd ELISA Kit (CAT#: V2LY-0626-LY2218)

Human Recombinant CFD protein, His Tag-1 (CAT#: V2LY-0526-LY3986)

Human CFD ELISA Kit (CAT#: V2LY-0626-LY711)

Rat Anti-CFD Recombinant Antibody (C2405) (CAT#: CBMAB-C2405-LY)

Mouse Recombinant CFD protein, His Tag (CAT#: V2LY-0526-LY8287)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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