Rat Cfd ELISA Kit (V2LY-0626-LY1396)

Name: Rat Cfd ELISA Kit
SKU: V2LY-0626-LY1396
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.142 ng/mL

Detection Range

0.3-90 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

28.4 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Complement Factor D

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Biological Process

Complement activation Source: ProtInc
Complement activation, alternative pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Notch signaling pathway Source: InterPro
Platelet degranulation Source: Reactome
Proteolysis Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Complement factor D deficiency (CFDD): An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Duan, C., Ma, Z., Wu, S., Ding, X., Tu, X., & Ye, J. (2021). Functional characterization of complement factor D on the defense against Gyrodactylus kobayashii (Monogenea) infection in goldfish (Carassius auratus). Aquaculture, 545, 737214.

Corvillo, F., González-Sánchez, L., López-Lera, A., Arjona, E., Ceccarini, G., Santini, F., ... & López-Trascasa, M. (2021). Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer–Simons syndrome). International Journal of Molecular Sciences, 22(12), 6608.

Langereis, J. D., van der Molen, R. G., de Kat Angelino, C., Henriet, S. S., de Jonge, M. I., Joosten, I., ... & van der Flier, M. (2021). Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing. Clinical & Translational Immunology, 10(4), e1256.

Wiles, J. A., Galvan, M. D., Podos, S. D., Geffner, M., & Huang, M. (2020). Discovery and development of the oral complement factor D inhibitor danicopan (ACH-4471). Current medicinal chemistry, 27(25), 4165-4180.

Qi, H., Wei, J., Gao, Y., Yang, Y., Li, Y., Zhu, H., ... & Yang, R. (2020). Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut. Communications biology, 3(1), 1-15.

Cho, H. Y., Park, H. S., Ko, E. J., Ryu, C. S., Kim, J. O., Kim, Y. R., ... & Kim, N. K. (2020). Association of complement factor D and H polymorphisms with recurrent pregnancy loss. International journal of molecular sciences, 21(1), 17.

Ezure, T., Sugahara, M., & Amano, S. (2019). Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D. BioFactors, 45(4), 556-562.

Yaspan, B. L., Williams, D. F., Holz, F. G., Regillo, C. D., Li, Z., Dressen, A., ... & MAHALO Study Investigators. (2017). Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration. Science translational medicine, 9(395).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Cfd ELISA Kit (CAT#: V2LY-0626-LY2218)

Human CFD ELISA Kit (CAT#: V2LY-0626-LY711)

Human Recombinant CFD protein, His Tag (CAT#: V2LY-0526-LY3985)

Human Recombinant CFD protein, His Tag-1 (CAT#: V2LY-0526-LY3986)

Mouse Recombinant CFD protein, His Tag (CAT#: V2LY-0526-LY8287)

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Mouse Anti-CFD Recombinant Antibody (5F20) (CAT#: CBMAB-C7568-LY)

Mouse Anti-CFD Recombinant Antibody (CBXF-1902) (CAT#: CBMAB-F2021-CQ)

Human Recombinant CFD protein, His Tag (CAT#: V2LY-0526-LY3985)

Rabbit Anti-CFD Recombinant Antibody (CBXF-1124) (CAT#: CBMAB-F0753-CQ)

Rat Anti-CFD Recombinant Antibody (C2405) (CAT#: CBMAB-C2405-LY)

Mouse Anti-CFD Recombinant Antibody (CBFYC-1753) (CAT#: CBMAB-C1815-FY)

Mouse Anti-CFD Recombinant Antibody (CBFYA-0194) (CAT#: CBMAB-X0275-FY)

Mouse Anti-CFD Recombinant Antibody (CBFYC-1751) (CAT#: CBMAB-C1813-FY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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