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Mouse Anti-CHD6 Recombinant Antibody (8C73) (CBMAB-C9102-LY)

This product is antibody recognizes CHD6. The antibody 8C73 immunoassay techniques such as: WB.
See all CHD6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8C73
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human CHD6
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromodomain Helicase DNA Binding Protein 6
Introduction
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Entrez Gene ID
84181
UniProt ID
Q8TD26
Alternative Names
Chromodomain Helicase DNA Binding Protein 6; Radiation-Induced Gene B Protein; ATP-Dependent Helicase CHD6; CHD-6; CHD5; RIGB;
Function
DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432).
Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.
(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.
Biological Process
Chromatin organization Source: UniProtKB-KW
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Nucleoplasm. Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin.
Involvement in disease
A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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