Rabbit Anti-CHI3L2 Recombinant Antibody (CBFYC-1833) (CBMAB-C1897-FY)

Name: Rabbit Anti-CHI3L2 Recombinant Antibody (CBFYC-1833)
SKU: CBMAB-C1897-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYC-1833

Application

ELISA, IHC-P

Immunogen

Recombinant Human YKL-39 / CHI3L2 protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:5,000-1:10,000
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Chitinase 3 Like 2

Introduction

The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

1117

UniProt ID

Q15782

Alternative Names

Chitinase 3 Like 2; Chondrocyte Protein 39; YKL-39; Chitinase-3-Like Protein 2; Chitinase 3-Like 2; CHIL2; YKL39

Function

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.

Biological Process

Carbohydrate metabolic process Source: InterPro
Chitin catabolic process Source: GO_Central

Cellular Location

Secreted

Ogunkolade, B. W., Adaikalakoteswari, A., Cardoso, S. R., Lowe, R., Patel, N., Rakyan, V., ... & Hitman, G. A. (2021). An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes. Epigenetics, 1-15.

Comabella, M., Sastre-Garriga, J., Borras, E., Villar, L. M., Saiz, A., Martínez-Yélamos, S., ... & Montalban, X. (2021). CSF Chitinase 3–Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis. Neurology-Neuroimmunology Neuroinflammation, 8(6).

Pusztai, C., Yusenko, M. V., Banyai, D., Szanto, A., & Kovacs, G. (2019). M2 macrophage marker chitinase 3-like 2 (CHI3L2) associates with progression of conventional renal cell carcinoma. Anticancer research, 39(12), 6939-6943.

Sanfilippo, C., Longo, A., Lazzara, F., Cambria, D., Distefano, G., Palumbo, M., ... & Di Rosa, M. (2017). CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients. Molecular and Cellular Neuroscience, 85, 162-169.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-CHI3L2 Recombinant Antibody (CBYY-C0496) (CAT#: CBMAB-C1481-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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