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Rat Anti-CHRD Recombinant Antibody (1365) (CBMAB-1365-CN)

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Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
1365
Application
WB
Immunogen
Mouse recombinant protein Chordin.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Chordin
Introduction
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Entrez Gene ID
12667
UniProt ID
Q9Z0E2
Alternative Names
Chd
Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).
Biological Process
BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: BHF-UCL
Floor plate development Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of mesenchymal cell proliferation Source: BHF-UCL
Skeletal system development Source: UniProtKB
Cellular Location
Secreted
PTM
Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.

Kumar, V., Goutam, R. S., Umair, Z., Park, S., Lee, U., & Kim, J. (2021). Foxd4l1. 1 Negatively Regulates Chordin Transcription in Neuroectoderm of Xenopus Gastrula. Cells, 10(10), 2779.

Kumar, V., Umair, Z., Kumar, S., Lee, U., & Kim, J. (2021). Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos. Biochemical and Biophysical Research Communications, 559, 168-175.

Wang, Y. W., Wu, C. H., Lin, T. Y., & Luo, C. W. (2021). Expression profiling of ovarian BMP antagonists reveals the potential interaction between TWSG1 and the chordin subfamily in the ovary. Molecular and Cellular Endocrinology, 538, 111457.

Abbas-Tehrani, H. (2021). The BMP antagonist CHORDIN as a regulator of osteoclast formation and function: an in vitro study.

Glister, C., Regan, S. L., Samir, M., & Knight, P. G. (2019). Gremlin, noggin, chordin and follistatin differentially modulate BMP-induced suppression of androgen secretion by bovine ovarian theca cells. Journal of molecular endocrinology, 62(1), 15-25.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rat Anti-CHRD Recombinant Antibody (C10980) (CAT#: CBMAB-C10980-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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