Human CHRD ELISA Kit (V2LY-0626-LY4406)

Name: Human CHRD ELISA Kit
SKU: V2LY-0626-LY4406
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.052 ng/mL

Detection Range

0.1-40 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

102.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Chordin

Function

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).

Biological Process

BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: BHF-UCL
Floor plate development Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of mesenchymal cell proliferation Source: BHF-UCL
Skeletal system development Source: UniProtKB

Cellular Location

Secreted

PTM

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.

Kumar, V., Goutam, R. S., Umair, Z., Park, S., Lee, U., & Kim, J. (2021). Foxd4l1. 1 Negatively Regulates Chordin Transcription in Neuroectoderm of Xenopus Gastrula. Cells, 10(10), 2779.

Kumar, V., Umair, Z., Kumar, S., Lee, U., & Kim, J. (2021). Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos. Biochemical and Biophysical Research Communications, 559, 168-175.

Wang, Y. W., Wu, C. H., Lin, T. Y., & Luo, C. W. (2021). Expression profiling of ovarian BMP antagonists reveals the potential interaction between TWSG1 and the chordin subfamily in the ovary. Molecular and Cellular Endocrinology, 538, 111457.

Abbas-Tehrani, H. (2021). The BMP antagonist CHORDIN as a regulator of osteoclast formation and function: an in vitro study.

Glister, C., Regan, S. L., Samir, M., & Knight, P. G. (2019). Gremlin, noggin, chordin and follistatin differentially modulate BMP-induced suppression of androgen secretion by bovine ovarian theca cells. Journal of molecular endocrinology, 62(1), 15-25.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-CHRD Recombinant Antibody (CBFYC-1849) (CAT#: CBMAB-C1913-FY)

Rat Anti-CHRD Recombinant Antibody (1365) (CAT#: CBMAB-1365-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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