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Mouse Anti-CHRDL1 Recombinant Antibody (CBWJC-2702) (CBMAB-C3795WJ)

This product is a Mouse antibody that recognizes CHRDL1. This antibody CBWJC-2702 can be used for immunoassay techniques such as: ICC, IF, WB.
See all CHRDL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBWJC-2702
Antibody Isotype
IgG1
Application
ICC, IF, WB

Basic Information

Immunogen
Recombinant Fragment Protein corresponding to 267-447aa of human CRDL1
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1M tris glycine, 150mM NaCl, 50% glycerol, pH 7.4
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chordin Like 1
Introduction
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Entrez Gene ID
Human91851
Mouse83453
UniProt ID
HumanQ9BU40
MouseQ920C1
Alternative Names
Chordin Like 1; Neurogenesin-1; Neuralin-1; Ventroptin; NRLN1; Megalocornea 1 (X-Linked); Chordin-Like Protein 1;
Function
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity).
May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
Biological Process
Cell differentiation Source: UniProtKB-KW
Cellular protein metabolic process Source: Reactome
Eye development Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Ossification Source: UniProtKB-KW
Post-translational protein modification Source: Reactome
Sequestering of BMP from receptor via BMP binding Source: Reactome
Cellular Location
Secreted
Involvement in disease
Megalocornea 1, X-linked (MGC1): An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation.

Deng, B., Chen, X., Xu, L., Zheng, L., Zhu, X., Shi, J., ... & Jiang, D. (2022). Chordin-like 1 is a novel prognostic biomarker and correlative with immune cell infiltration in lung adenocarcinoma. Aging, 14(undefined).

Mamoor, S. (2021). Differential expression of CHRDL1 in cancer of the vulva.

Mamoor, S. (2021). Differential expression of chordin-like 1 in cancers of the breast.

Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., ... & Warman, M. L. (2020). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea, 39(9), 1145-1150.

Blanco-Suarez, E., & Allen, N. J. (2020). Astrocyte-secreted chordin-like 1 regulates spine density after ischemic stroke. bioRxiv.

Huang, J., Wei, X., Ma, W., & Yuan, Z. (2020). The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells. Biochemical and Biophysical Research Communications, 527(1), 187-193.

Liu, T., Li, B., Zheng, X. F., Jiang, S. D., Zhou, Z. Z., Xu, W. N., ... & Jiang, L. S. (2019). Chordin-like 1 improves osteogenesis of bone marrow mesenchymal stem cells through enhancing BMP4-SMAD pathway. Frontiers in endocrinology, 10, 360.

Liu, Y., Warman, M., Sullivan, D. A., Hann, S., & Chen, D. (2019). Ocular manifestations of chordin-like 1 (Chrdl1) knockout mice. Investigative Ophthalmology & Visual Science, 60(9), 4150-4150.

Blanco-Suarez, E., Liu, T. F., Kopelevich, A., & Allen, N. J. (2018). Astrocyte-secreted chordin-like 1 drives synapse maturation and limits plasticity by increasing synaptic GluA2 AMPA receptors. Neuron, 100(5), 1116-1132.

Pei, Y. F., Zhang, Y. J., Lei, Y., Wu, D. W., Ma, T. H., & Liu, X. Q. (2017). Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. Oncotarget, 8(14), 23155.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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