Human CHRDL1 ELISA Kit (V2LY-0626-LY4407)

Name: Human CHRDL1 ELISA Kit
SKU: V2LY-0626-LY4407
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.027 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

52.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Chordin Like 1

Function

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity).
May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.

Biological Process

Cell differentiation Source: UniProtKB-KW
Cellular protein metabolic process Source: Reactome
Eye development Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Ossification Source: UniProtKB-KW
Post-translational protein modification Source: Reactome
Sequestering of BMP from receptor via BMP binding Source: Reactome

Cellular Location

Secreted

Involvement in disease

Megalocornea 1, X-linked (MGC1): An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation.

Deng, B., Chen, X., Xu, L., Zheng, L., Zhu, X., Shi, J., ... & Jiang, D. (2022). Chordin-like 1 is a novel prognostic biomarker and correlative with immune cell infiltration in lung adenocarcinoma. Aging, 14(undefined).

Mamoor, S. (2021). Differential expression of CHRDL1 in cancer of the vulva.

Mamoor, S. (2021). Differential expression of chordin-like 1 in cancers of the breast.

Chen, D., Liu, Y., Shu, G., Chen, C., Sullivan, D. A., Kam, W. R., ... & Warman, M. L. (2020). Ocular Manifestations of Chordin-like 1 Knockout Mice. Cornea, 39(9), 1145-1150.

Blanco-Suarez, E., & Allen, N. J. (2020). Astrocyte-secreted chordin-like 1 regulates spine density after ischemic stroke. bioRxiv.

Huang, J., Wei, X., Ma, W., & Yuan, Z. (2020). The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells. Biochemical and Biophysical Research Communications, 527(1), 187-193.

Liu, T., Li, B., Zheng, X. F., Jiang, S. D., Zhou, Z. Z., Xu, W. N., ... & Jiang, L. S. (2019). Chordin-like 1 improves osteogenesis of bone marrow mesenchymal stem cells through enhancing BMP4-SMAD pathway. Frontiers in endocrinology, 10, 360.

Liu, Y., Warman, M., Sullivan, D. A., Hann, S., & Chen, D. (2019). Ocular manifestations of chordin-like 1 (Chrdl1) knockout mice. Investigative Ophthalmology & Visual Science, 60(9), 4150-4150.

Blanco-Suarez, E., Liu, T. F., Kopelevich, A., & Allen, N. J. (2018). Astrocyte-secreted chordin-like 1 drives synapse maturation and limits plasticity by increasing synaptic GluA2 AMPA receptors. Neuron, 100(5), 1116-1132.

Pei, Y. F., Zhang, Y. J., Lei, Y., Wu, D. W., Ma, T. H., & Liu, X. Q. (2017). Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. Oncotarget, 8(14), 23155.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Chrdl1 ELISA Kit (CAT#: V2LY-0626-LY2129)

Mouse Chrdl1 ELISA Kit (CAT#: V2LY-0626-LY2167)

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Mouse Anti-CHRDL1 Recombinant Antibody (
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Mouse Anti-CHRDL1 Recombinant Antibody (3H1-F6-A10) (CAT#: CBMAB-C6272-LY)

Mouse Chrdl1 ELISA Kit (CAT#: V2LY-0626-LY2167)

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Mouse Anti-CHRDL1 Recombinant Antibody (CB445A) (CAT#: CBMAB-CA445LY)

Isotype control

For research use only. Not intended for any clinical use.

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