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Rat Anti-CHRDL2 Recombinant Antibody (CBFYC-0493) (CBMAB-C0543-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-0493
Antibody Isotype
IgG2a
Application
IHC, IP, WB

Basic Information

Immunogen
Recombinant mouse Chordin-like 2/CHRDL2 Gln24-Leu426.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml
IP25 µg/ml
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chordin Like 2
Introduction
This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration.
Entrez Gene ID
25884
UniProt ID
Q6WN34
Alternative Names
Chordin Like 2; Breast Tumor Novel Factor 1; Chordin-Related Protein 2; BNF1; CHL2; Chordin-Like Protein 2; BNF-1
Function
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).
Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Biological Process
Cartilage development Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Ossification Source: UniProtKB-KW
Cellular Location
Isoform 1&2: Secreted
Isoform 3&4&5: Cytoplasm
PTM
Phosphorylated by FAM20C in the extracellular medium.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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