CHRDL2

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]
Full Name
Chordin Like 2
Function
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).
Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Biological Process
Cartilage development Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Ossification Source: UniProtKB-KW
Cellular Location
Isoform 1&2: Secreted
Isoform 3&4&5: Cytoplasm
PTM
Phosphorylated by FAM20C in the extracellular medium.
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Anti-CHRDL2 antibodies

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Mouse Anti-CHRDL2 Recombinant Antibody (CBXC-1055) (CBMAB-C1319-CQ)

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Target: CHRDL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1055
Application*: WB, F
Datasheet SDS

Rat Anti-CHRDL2 Recombinant Antibody (CBFYC-0493) (CBMAB-C0543-FY)

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Target: CHRDL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0493
Application*: IH, IP, WB
Datasheet SDS

Rat Anti-CHRDL2 Recombinant Antibody (C5514) (CBMAB-C5514-LY)

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Target: CHRDL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: C5514
Application*: WB, IP
Datasheet SDS

Human CHRDL2 ELISA Kit (V2LY-0626-LY4408)

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Target: CHRDL2
Sensitivity: 0.0099 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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